B5RRI6 (B5RRI6_BORRA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Autoinducer-2 production protein EMBL ACH94620.1
EC=4.4.1.21 EMBL ACH94620.1

Gene names

Ordered Locus Names:

BRE_376

Organism

Borrelia recurrentis (strain A1) [Complete proteome] [HAMAP]

Taxonomic identifier

412418 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815
Catalytic activity	S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815
Cofactor	Binds 1 iron ion per subunit By similarity. SAAS SAAS003815
Subunit structure	Homodimer By similarity. SAAS SAAS003815

Ontologies

Keywords
Biological process	Autoinducer synthesis SAAS SAAS003815 Quorum sensing SAAS SAAS003815
Ligand	Iron SAAS SAAS003815 Metal-binding SAAS SAAS003815
Molecular function	Lyase SAAS SAAS003815 EMBL ACH94620.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	S-ribosylhomocysteine lyase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5RRI6 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: 91B872C600C656C0	FASTA	185	21,721
	10 20 30 40 50 60 MYIRTFWEKR IRMGKIRFRR HNQKGVSNMN KISSFTIDHT KLQPGIYISR KDTFDNLTLT 70 80 90 100 110 120 TVDIRMKTPN KEPVINNAEI HTIEHIGATL LRNNKVWGDK IIYFGPMGCR TGFYLILFGN 130 140 150 160 170 180 YESKDLIDLI SWLFNEITNF QGNVIGATEK ECGNYQDHNL NMAKYESSKY LETLENIKKE NLIYP

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000993 Genomic DNA. Translation: ACH94620.1.
RefSeq	YP_002222841.1. NC_011244.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B5RRI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000005660; EBBORP00000005235; EBBORG00000005660.
GeneID	6918918.
GenomeReviews	Gene locus BRE_376 in contig CP000993_GR.
KEGG	bre:BRE_376.
PATRIC	20569909. VBIBorRec40566_0402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007432.
HOGENOM	HBG347473.
OMA	TTFDIRM.
ProtClustDB	PRK02260.
Family and domain databases
HAMAP	MF_00091. LuxS. [Tree]
InterPro	IPR011249. Metalloenz_metal-bd. IPR003815. S-ribosylhomocysteinase. [Graphical view]
Gene3D	G3DSA:3.30.1360.80. S-ribosylhomocysteinase. 1 hit.
KO	K07173.
Pfam	PF02664. LuxS. 1 hit. [Graphical view]
PIRSF	PIRSF006160. AI2. 1 hit.
PRINTS	PR01487. LUXSPROTEIN.
ProDom	PD013172. S-ribosylhomocysteinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B5RRI6_BORRA

Accession

Primary (citable) accession number: B5RRI6

Entry history

Integrated into UniProtKB/TrEMBL:	November 4, 2008
Last sequence update:	November 4, 2008
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)