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B5RRI1

- SYE_BORRA

UniProt

B5RRI1 - SYE_BORRA

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Borrelia recurrentis (strain A1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi121 – 1211ZincUniRule annotation
Metal bindingi123 – 1231ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi150 – 1501ZincUniRule annotation
Binding sitei269 – 2691ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
  4. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBREC412418:GJIA-371-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:BRE_371
OrganismiBorrelia recurrentis (strain A1)
Taxonomic identifieri412418 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
ProteomesiUP000000612: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Glutamate--tRNA ligasePRO_0000367620Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi412418.BRE_371.

Structurei

3D structure databases

ProteinModelPortaliB5RRI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 3411"HIGH" regionAdd
BLAST
Motifi266 – 2705"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiWLPEEMG.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B5RRI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFQKRTFFI KRGCVLNIRV RYAPSPTGLQ HIGGIRTALF NYFFAKSFNG
60 70 80 90 100
KFLLRIEDTD QTRYYKEAEE DLYQSLAWLG IDFDEGPTCG GSYSPYIQSQ
110 120 130 140 150
RTEIYRKYAK ELIESGNAYY CYCSPDRLER IRKIQTINKM VPGYDRHCRH
160 170 180 190 200
LNKDEIKDAL SLGISPVIRF KIPFDGETSF NDILLGKITW ANKDISPDPV
210 220 230 240 250
ILKSDGFPTY HLANVVDDHL MEISHVLRAQ EWISSGSLHV LLYNAFGWNP
260 270 280 290 300
PIYCHLPMVM GSDGQKLSKR HGATALKQFI DDGYLPEAII NYVTLLGWSY
310 320 330 340 350
DGKSEFFTKN ELQKLFSIDK ISKSPAVFDY NKLDFFNSHY IRTKEDHELA
360 370 380 390 400
ELLLPFLQKA GYIKKDSNSC DKEKLLLLVP LIKPRIRKLG DAVGMLRFFY
410 420 430 440 450
TNISTWNVNE FLGKKKTVRD IYLLLEKIKP VLEGFETRIL SENEQIFYNF
460 470 480 490 500
AKENNLKIGE VLIPIRIAVL GSKVSPPLFD SLQLLGKVKV FDRINKAQDF

LKKYEL
Length:506
Mass (Da):58,487
Last modified:November 4, 2008 - v1
Checksum:iC76EB3D9597B2950
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000993 Genomic DNA. Translation: ACH94615.1.
RefSeqiWP_012538855.1. NC_011244.1.
YP_002222836.1. NC_011244.1.

Genome annotation databases

EnsemblBacteriaiACH94615; ACH94615; BRE_371.
GeneIDi6918913.
KEGGibre:BRE_371.
PATRICi20569899. VBIBorRec40566_0397.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000993 Genomic DNA. Translation: ACH94615.1 .
RefSeqi WP_012538855.1. NC_011244.1.
YP_002222836.1. NC_011244.1.

3D structure databases

ProteinModelPortali B5RRI1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412418.BRE_371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH94615 ; ACH94615 ; BRE_371 .
GeneIDi 6918913.
KEGGi bre:BRE_371.
PATRICi 20569899. VBIBorRec40566_0397.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi WLPEEMG.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci BREC412418:GJIA-371-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
    Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1.

Entry informationi

Entry nameiSYE_BORRA
AccessioniPrimary (citable) accession number: B5RRI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3