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B5RRC2 (MRAY_BORRA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:BRE_310
OrganismBorrelia recurrentis (strain A1) [Complete proteome] [HAMAP]
Taxonomic identifier412418 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090597

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane61 – 8323Helical; Potential
Transmembrane88 – 10518Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane254 – 27421Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane328 – 34821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B5RRC2 [UniParc].

Last modified November 4, 2008. Version 1.
Checksum: 448F6DD2C1F5A568

FASTA35139,539
        10         20         30         40         50         60 
MFCFLGLRLL KYITFRTAYA TIFAFLLALI FGPFIISRLK KLKLDQILRK DGPKHHLSEK 

        70         80         90        100        110        120 
MGIPTMGGVL IFFCVLVSLF FWIHFFNIYF LIVLFVMVSF ACLGFTDDLL KIKRKNSDGL 

       130        140        150        160        170        180 
NPKFKIYGQI LFSFISVVML YYFGGEHVSI LYFPFFKSLK LDLGILYIPF GMFVLISASN 

       190        200        210        220        230        240 
SFNLTDGLDG LAIGLSIVVI GALIIIAYLT SRVDFALYLN IPNVKGCEEL VIFLGALLGG 

       250        260        270        280        290        300 
SFGFLWFNAY PAKIMMGDTG SLSIGAVLGM VALILKSEIL FAILAGVFVV ETLSVIIQVV 

       310        320        330        340        350 
VYKKTKKRVF KMAPLHHHFE ELGWSEMQVV IRFWIIGLIF AILALSTIKI R

« Hide

References

[1]"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000993 Genomic DNA. Translation: ACH94556.1.
RefSeqYP_002222777.1. NC_011244.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB5RRC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBORT00000005501; EBBORP00000005076; EBBORG00000005501.
GeneID6918852.
GenomeReviewsGene locus BRE_310 in contig CP000993_GR.
KEGGbre:BRE_310.
PATRIC20569771. VBIBorRec40566_0333.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007216.
HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BORRA
AccessionPrimary (citable) accession number: B5RRC2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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