Reviewed, UniProtKB/Swiss-Prot B5RR63 (NTPA_BORRA)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

BRE_247

Organism

Borrelia recurrentis (strain A1) [Complete proteome] [HAMAP]

Taxonomic identifier

412418 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	199 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity. HAMAP MF_01405
Subunit structure	Homodimer By similarity. HAMAP MF_01405
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 199	199	Nucleoside-triphosphatase HAMAP MF_01405		PRO_1000145483

Sequences

	Sequence		Length	Mass (Da)
	B5RR63-1 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: 14D755659B6F553C	FASTA	199	23,167
	10 20 30 40 50 60 MKTLFFATSN INKINEVKQI LDIPKIKIEI PQNFDIKETG KTFKENSLLK AKALFKILNN 70 80 90 100 110 120 KQPVFSEDSG LCIEALNMEP GIYSKRYDQY KLGKKLDNNE KNHLIIDLMR EQNNRTAYFI 130 140 150 160 170 180 CVISYIDVDG TINNFEGMLK GTIALNIDYY QKNGFGYNPI FLTTNNKRLS ELNLEEKNKI 190 SHRGIAFDKF KKFLMQFLD

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000993 Genomic DNA. Translation: ACH94497.1.
RefSeq	YP_002222718.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6918789.
GenomeReviews	Gene locus BRE_247 in contig CP000993_GR.
KEGG	bre:BRE_247.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG697237.
OMA	FAYDSIF.
Family and domain databases
HAMAP	MF_01405. Nucleoside_triphosp. [Tree]
InterPro	IPR002637. Ham1p-like. IPR020922. Nucleoside-triphosphatase. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_BORRA

Accession

Primary (citable) accession number: B5RR63

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 4, 2008
Last modified:	February 9, 2010
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)