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B5RR18 (DDL_BORRA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:BRE_197
OrganismBorrelia recurrentis (strain A1) [Complete proteome] [HAMAP]
Taxonomic identifier412418 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000091163

Regions

Domain134 – 344211ATP-grasp
Nucleotide binding167 – 22256ATP By similarity

Sites

Metal binding2971Magnesium or manganese 1 By similarity
Metal binding3111Magnesium or manganese 1 By similarity
Metal binding3111Magnesium or manganese 2 By similarity
Metal binding3131Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B5RR18 [UniParc].

Last modified November 4, 2008. Version 1.
Checksum: 142ABD18480DBA05

FASTA36441,219
        10         20         30         40         50         60 
MKKNLMLIFG GVSFEHEISL RSAYGIYSSL LKLDKYNVFS IFVDKVTGIW YLLDSVPSSA 

        70         80         90        100        110        120 
ELIKRHTTSI VNFIPGCGIF VNNKSLEIDV IFPIIHGRTG EDGAIQGFVK MMDIPCVGAG 

       130        140        150        160        170        180 
ILGSAISINK YFCKVLLKSF NIPVVSFIGF KKDDYILNKE GIKEDINNKL NYPVIVKPSV 

       190        200        210        220        230        240 
LGSSIGINVA YNVSQIEKYI EEAFEYDLTV VVEKFIKARE IECAVIGNDQ IKIFTPGEIV 

       250        260        270        280        290        300 
VQDFIFYDYD AKYSTVPGDS IVFNIPAHLD MKHLLDIKEY AFLTYKYLEL RGMARIDFLI 

       310        320        330        340        350        360 
SKDTNLLYVN EVNTIPGFTD ISMFAKMCEH DGLSYESLVD KLITLAFESY KKRKDKIDFT 


RLES 

« Hide

References

[1]"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: A1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000993 Genomic DNA. Translation: ACH94452.1.
RefSeqYP_002222673.1. NC_011244.1.

3D structure databases

ProteinModelPortalB5RR18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING412418.BRE_197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH94452; ACH94452; BRE_197.
GeneID6919403.
KEGGbre:BRE_197.
PATRIC20569527. VBIBorRec40566_0215.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK14570.

Enzyme and pathway databases

BioCycBREC412418:GJIA-197-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_BORRA
AccessionPrimary (citable) accession number: B5RR18
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways