B5RQV4 (KCY_BORRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	BRE_131

Organism

Borrelia recurrentis (strain A1) [Complete proteome] [HAMAP]

Taxonomic identifier

412418 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00238
Subcellular location	Cytoplasm By similarity HAMAP MF_00238.
Sequence similarities	Belongs to the cytidylate kinase family. Type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Cytidylate kinase HAMAP MF_00238		PRO_1000100648
Regions
	Nucleotide binding	7 – 15	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5RQV4 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: A7C9382978091CCB	FASTA	218	25,114
	10 20 30 40 50 60 MIIAIDGPSA SGKSSVSKAL SMKLGFKFIS SGYLYRIITL IAQRFTLNEY DLLNESKLVD 70 80 90 100 110 120 LISQNDIKYN DNSFLLNGVD VISHILTEKI DFQVSLYSSY VNIRKIVNKK LREIVKIQDD 130 140 150 160 170 180 DYIIEGRDIT TVVFPEAKIK IYLDASVEVR TLRRYNQRDD DMALIELEQA LEKRDEIDQN 190 200 210 KEYGKLKLGK GVFYIDTSYK SLDDVCDIII KTFNLKKK

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: A1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000993 Genomic DNA. Translation: ACH94388.1.
RefSeq	YP_002222609.1. NC_011244.1.
3D structure databases
ProteinModelPortal	B5RQV4.
ModBase	Search...
Protein-protein interaction databases
STRING	B5RQV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBORT00000005394; EBBORP00000004969; EBBORG00000005394.
GeneID	6918756.
GenomeReviews	Gene locus BRE_131 in contig CP000993_GR.
KEGG	bre:BRE_131.
PATRIC	20569389. VBIBorRec40566_0146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000007027.
HOGENOM	HBG354377.
OMA	DIGTVIC.
ProtClustDB	CLSK507373.
Family and domain databases
HAMAP	MF_00238. Cytidyl_kinase_type1. [Tree]
InterPro	IPR003136. Cytidylate_kin. IPR011994. Cytidylate_kinase_dom. [Graphical view]
KO	K00945.
PANTHER	PTHR21299:SF2. Cytidylate_kin. 1 hit.
Pfam	PF02224. Cytidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00017. Cmk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_BORRA

Accession

Primary (citable) accession number: B5RQV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 4, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program