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Protein

Primosomal protein N'

Gene

priA

Organism
Borrelia recurrentis (strain A1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi157 – 1648ATPUniRule annotation
Zinc fingeri368 – 38013C4-typeUniRule annotationAdd
BLAST
Zinc fingeri395 – 41117C4-typeUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBREC412418:GJIA-19-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Primosomal protein N'UniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase PriAUniRule annotation
Gene namesi
Name:priAUniRule annotationImported
Ordered Locus Names:BRE_19Imported
OrganismiBorrelia recurrentis (strain A1)Imported
Taxonomic identifieri412418 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia
ProteomesiUP000000612 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

PrimosomeUniRule annotation

Interactioni

Subunit structurei

Component of the primosome.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini144 – 311168Helicase ATP-bindingUniRule annotationAdd
BLAST
Domaini403 – 555153Helicase C-terminalUniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi254 – 2574DEAH boxUniRule annotation

Sequence similaritiesi

Belongs to the helicase family. PriA subfamily.UniRule annotation
Contains 1 helicase ATP-binding domain.UniRule annotation
Contains 1 helicase C-terminal domain.UniRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri368 – 38013C4-typeUniRule annotationAdd
BLAST
Zinc fingeri395 – 41117C4-typeUniRule annotationAdd
BLAST

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiCOG1198.
HOGENOMiHOG000037414.
KOiK04066.
OMAiICCPNCS.
OrthoDBiEOG6KT2K4.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00983. PriA.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR005259. PriA.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00595. priA. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5RQJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDNLKQNFY YDIAFNIPIN RLFLYKYKLT LKTGTRVITN FHGKETIGII
60 70 80 90 100
IKRYYKEELK EDFTFSIKYI LKVIDDHPII TEHNINLARW ISKKTFSGFG
110 120 130 140 150
ETLFCGLPKI STSNKKIKNN KSESPKSKVS IQLNEEQNKI YKDIIQSSIQ
160 170 180 190 200
NTFYLFGVPG SGKTEIFIKL CENYLEQKKQ IIFLIPEISL GYQIIQRLKS
210 220 230 240 250
SLSTNNIYEY NSKVSNSNKI AIWNKVKNGE SLIILGIKSA LMLPFTNLGL
260 270 280 290 300
IIMDEEHEHT YKSENTPRFH SRHIGFFLQN TFNAKFIMGS ATPSLEAYLA
310 320 330 340 350
MENNQIKKMI LKNKFLTKTL KELKIIDMKK EPQIISSELL YSIQKSILEK
360 370 380 390 400
RQALIFINKR GYSNTLECKI CEHIICCPNC SVNLTYHQNE NKLICHYCNH
410 420 430 440 450
KTNIISTCPK CNSKDIMYKT YGIQFVEKEL KKFLPNARIA RIDSNINQKE
460 470 480 490 500
ISQSINAFEN EQLDILIGTQ IIAKGFNFKQ IKTLGIINAD IGIDFPDFRS
510 520 530 540 550
SEKIFAIISQ VLGRAARFKS DNTIIIQTKN PNYYAIKYAY EGKYEEFYQE
560 570 580 590 600
EIKIRKELNY PPFKKIIRIV VRSQKQEAAK HKCSEFFDIS KEFLNDDIEY
610 620 630 640 650
IGPSKAPMSK ISKYYRYNIL YLSKTFNPLE KLIRNTKERI KNTKDIYIEI

DYYPLSLL
Length:658
Mass (Da):76,853
Last modified:November 4, 2008 - v1
Checksum:i0FE7BD1866ACE37D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000993 Genomic DNA. Translation: ACH94281.1.
RefSeqiWP_012538597.1. NC_011244.1.

Genome annotation databases

EnsemblBacteriaiACH94281; ACH94281; BRE_19.
KEGGibre:BRE_19.
PATRICi20569161. VBIBorRec40566_0033.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000993 Genomic DNA. Translation: ACH94281.1.
RefSeqiWP_012538597.1. NC_011244.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH94281; ACH94281; BRE_19.
KEGGibre:BRE_19.
PATRICi20569161. VBIBorRec40566_0033.

Phylogenomic databases

eggNOGiCOG1198.
HOGENOMiHOG000037414.
KOiK04066.
OMAiICCPNCS.
OrthoDBiEOG6KT2K4.

Enzyme and pathway databases

BioCyciBREC412418:GJIA-19-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
HAMAPiMF_00983. PriA.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR005259. PriA.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR00595. priA. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
    Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: A1Imported.

Entry informationi

Entry nameiB5RQJ7_BORRA
AccessioniPrimary (citable) accession number: B5RQJ7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 4, 2008
Last sequence update: November 4, 2008
Last modified: July 22, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.