B5RMX9 (PTH_BORDL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-tRNA hydrolase
Short name=PTH
EC=3.1.1.29

Gene names

Name:	pth
Ordered Locus Names:	BDU_793

Organism

Borrelia duttonii (strain Ly) [Complete proteome] [HAMAP]

Taxonomic identifier

412419 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Spirochaetaceae › Borrelia › Borrelia duttonii

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity. HAMAP-Rule MF_00083
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP-Rule MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	translation Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Peptidyl-tRNA hydrolase HAMAP-Rule MF_00083		PRO_1000092911

Sequences

	Sequence		Length	Mass (Da)
	B5RMX9 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: AE79B567EEC62D5A	FASTA	188	21,062
	10 20 30 40 50 60 MNLLIVGLGN PGSNFLHTRH NVGFGLIDKL VMKNALSLRK AKNYEYADFN IDSRRIVLIK 70 80 90 100 110 120 PLTYMNLSGN IFPFVFSKFY MKINNLLVVV DNVDLPLGKC RLRKVGGAST HNGLRSISES 130 140 150 160 170 180 LGSTKYGRLY IGVGNNSAFA LKDFVLSKFN DSELVRVKNV FNFLSEEILG IDEFSFEHKI ATINSSSF

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ly.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000976 Genomic DNA. Translation: ACH93715.1.
RefSeq	YP_002222421.1. NC_011229.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	412419.BDU_793.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACH93715; ACH93715; BDU_793.
GeneID	6918019.
KEGG	bdu:BDU_793.
PATRIC	20563708. VBIBorDut9941_0798.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0193.
HOGENOM	HOG000004797.
KO	K01056.
OMA	FRKNREF.
ProtClustDB	PRK05426.
Enzyme and pathway databases
BioCyc	BDUT412419:GJ78-793-MONOMER.
Family and domain databases
Gene3D	3.40.50.1470. 1 hit.
HAMAP	MF_00083. Pept_tRNA_hydro_bact.
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
PANTHER	PTHR17224. PTHR17224. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
SUPFAM	SSF53178. Pept_tRNA_hydro. 1 hit.
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BORDL

Accession

Primary (citable) accession number: B5RMX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 4, 2008
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program