Reviewed, UniProtKB/Swiss-Prot B5RMW0 (GCP_BORDL)

Names and origin

Protein names

Recommended name:
    Probable O-sialoglycoprotein endopeptidase
      Short name=Glycoprotease
    EC=3.4.24.57

Gene names

Name:	gcp
Ordered Locus Names:	BDU_773

Organism

Borrelia duttonii (strain Ly) [Complete proteome] [HAMAP]

Taxonomic identifier

412419 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated. HAMAP MF_01445
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the peptidase M22 family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Probable O-sialoglycoprotein endopeptidase HAMAP MF_01445		PRO_1000145949
Sites
	Metal binding	110	1	Zinc Potential
	Metal binding	114	1	Zinc Potential

Sequences

	Sequence		Length	Mass (Da)
	B5RMW0-1 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: 55EAA41106EC8B4C	FASTA	338	37,496
	10 20 30 40 50 60 MKVLGIESSC DDCCAAIVEN GNTILSNIKL SQKEHKKYYG IVPEIASRLH TEFIMYVCQQ 70 80 90 100 110 120 AIISAQINIS EIDLIAVTSQ PGLIGSLIVG VNFAKGLSIA LKKPLICIDH ILGHLYAPLL 130 140 150 160 170 180 NHTIEYPFLS LVLSGGHTIL AKQNNFDDIE ILGRTLDDAC GEAFDKIAKH YKMGFPGGPN 190 200 210 220 230 240 IEKLAIDGNQ YAFNFPITIF DKKENRYDFS YSGLKTACIH QLEKFKNNNA QITNNNIAAS 250 260 270 280 290 300 FQRAAFENLI IPIKRAIKDT NIKKLIISGG VASNLYLREK IKNLEIETYY PPIDLCTDNA 310 320 330 AMIAGIGYLM YLKYGASSIE TNANSRIENY KYTKGVKL

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000976 Genomic DNA. Translation: ACH93696.1.
RefSeq	YP_002222402.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	M22.001.
Genome annotation databases
GeneID	6917999.
GenomeReviews	Gene locus BDU_773 in contig CP000976_GR.
KEGG	bdu:BDU_773.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CKRALKQ.
Family and domain databases
HAMAP	MF_01445. [Tree]
InterPro	IPR009180. Pept_M22_Osialgl. IPR000905. Peptidase_M22. IPR017860. Peptidase_M22_CS. IPR017861. Peptidase_M22_subgr. [Graphical view]
PANTHER	PTHR11735. Pept_M22_Osialgl. 1 hit.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. gcp. 1 hit.
PROSITE	PS01016. GLYCOPROTEASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_BORDL

Accession

Primary (citable) accession number: B5RMW0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	November 4, 2008
Last modified:	November 3, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)