Reviewed, UniProtKB/Swiss-Prot B5RMP6 (COAD_BORDL)

Names and origin

Protein names

Recommended name:
    Phosphopantetheine adenylyltransferase
    EC=2.7.7.3
Alternative name(s):
    Pantetheine-phosphate adenylyltransferase
      Short name=PPAT
    Dephospho-CoA pyrophosphorylase

Gene names

Name:	coaD
Ordered Locus Names:	BDU_704

Organism

Borrelia duttonii (strain Ly) [Complete proteome] [HAMAP]

Taxonomic identifier

412419 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial coaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_1000096765

Sequences

	Sequence		Length	Mass (Da)
	B5RMP6-1 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: 12A4217EEF3AD044	FASTA	165	19,171
	10 20 30 40 50 60 MRAALFPGSF DPITWGHIDL VKRASLIFDK VIVLVANNSN KSYLLSDIER YELTFEVIMS 70 80 90 100 110 120 LGWTKIFVDK YDGVILDYAL KNNIGFIVRG VRAFHDFEFE FERYVVNNKL NSSIDTVFLP 130 140 150 160 SSDKYLFVRS DLVKELIKNK NFNLSNFIPE LVQKKLKSKF IDKLS

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000976 Genomic DNA. Translation: ACH93632.1.
RefSeq	YP_002222338.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6917930.
GenomeReviews	Gene locus BDU_704 in contig CP000976_GR.
KEGG	bdu:BDU_704.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG288308.
OMA	VRQIAAM.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. coaD_prev_kdtB. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_BORDL

Accession

Primary (citable) accession number: B5RMP6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 4, 2008
Last modified:	February 9, 2010
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)