Reviewed, UniProtKB/Swiss-Prot B5RME6 (SYR_BORDL)

Names and origin

Protein names

Recommended name:
    Arginyl-tRNA synthetase
    EC=6.1.1.19
Alternative name(s):
    Arginine--tRNA ligase
      Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	BDU_595

Organism

Borrelia duttonii (strain Ly) [Complete proteome] [HAMAP]

Taxonomic identifier

412419 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

Protein attributes

Sequence length	585 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP arginine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 585	585	Arginyl-tRNA synthetase HAMAP MF_00123		PRO_1000095335
Regions
	Motif	127 – 137	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	B5RME6-1 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: CE96893EF201D2AE	FASTA	585	67,249
	10 20 30 40 50 60 MIKTIKADLK NKIQKTIKEL ALSSNIKLDK INIVMQKPPK SEMGDLSILI FEFSKILKLS 70 80 90 100 110 120 IPVITQEIIK QIGNEYKTKS MGPYLNIKFN RKEYIQNTIK KVNKEKENYG ANNSLQNKKT 130 140 150 160 170 180 IIEFSSPNTN KPLHVGHLRN DIIGESLSRI LKASGSKVTK INLINDRGTH ICKSMLAYKK 190 200 210 220 230 240 FGNNITPEIA QKKGDHLIGD FYVKYNEYAS QNSEIAENEI QQLLCQWEQG DEKTVQLWTK 250 260 270 280 290 300 LNKWAIDGIK ETYNTTNITF DKIYLESEIF KIGREVVING LKEGLCYKRE DGAICINIPT 310 320 330 340 350 360 EKNNIDNQNF KQKVLLRANG TSIYLTQDLG NIVARKNEFD FDEMIYVVGS EQIHHFKTLF 370 380 390 400 410 420 YVADKLGVTN ENNLIHLSYG MVNLPEGKMK SREGNIIDAD NLIHDLSQST MLELKKRYEN 430 440 450 460 470 480 EQNLQKLALN ISLGAIHYYL LKTAIHKDIL FNKTESLSFT GNSGPYIQYV GARINSILDK 490 500 510 520 530 540 YNNLNLANKN TNFDLLVNEN EWEIIKIISE FEEYIIKASK DRNPSIIANY SYLLAKNFST 550 560 570 580 YYQDTKIIDK DNLELTHARI DLAKAVLQTI KNCMHLLNIP YIQKM

References

[1]

"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii." Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M. PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000976 Genomic DNA. Translation: ACH93532.1.
RefSeq	YP_002222238.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6917821.
GenomeReviews	Gene locus BDU_595 in contig CP000976_GR.
KEGG	bdu:BDU_595.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	AYKKWGN.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ic. IPR015945. Arg-tRNA-synth_Ic_core. IPR005148. Arg-tRNA-synth_Ic_N. IPR008909. DALR_anticod_bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM00836. DALR_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00456. argS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_BORDL

Accession

Primary (citable) accession number: B5RME6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	November 4, 2008
Last modified:	February 9, 2010
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)