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B5RL84

- UPPP_BORDL

UniProt

B5RL84 - UPPP_BORDL

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, BDU_261
Organism
Borrelia duttonii (strain Ly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBDUT412419:GJ78-261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:BDU_261
OrganismiBorrelia duttonii (strain Ly)
Taxonomic identifieri412419 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
ProteomesiUP000000611: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei147 – 16721Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Transmembranei246 – 26621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphataseUniRule annotation
PRO_1000197351Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi412419.BDU_261.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiPIVFDIY.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5RL84-1 [UniParc]FASTAAdd to Basket

« Hide

MDNILRVIIL GFVQGISEFL PISSSGHLLL LKKFMNIDLP IVFDIYLHFA    50
TVLVVIIYYR RRILELVMVF IKFILRKLKM TELDSSNLNL ILLILIITFF 100
TALIGIFIEK FKVLFTFKLV LFNFIVTSIL LFLIEFRIKI FNFKKNIFFS 150
GLLIGIMQGI GAMPGISRSG ITIFASILLG FSRTKSLEIS FLSLIPIVFG 200
SLFLKYNDLF KSDIIFNIFE INLGAIFAFI FGLFSISLFV KMLKNSKLYY 250
FSIYLVSVVS LVYFLV 266
Length:266
Mass (Da):30,629
Last modified:November 4, 2008 - v1
Checksum:iA05630080BCE2150
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000976 Genomic DNA. Translation: ACH93213.1.
RefSeqiWP_012538024.1. NC_011229.1.
YP_002221919.1. NC_011229.1.

Genome annotation databases

EnsemblBacteriaiACH93213; ACH93213; BDU_261.
GeneIDi6918345.
KEGGibdu:BDU_261.
PATRICi20562628. VBIBorDut9941_0287.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000976 Genomic DNA. Translation: ACH93213.1 .
RefSeqi WP_012538024.1. NC_011229.1.
YP_002221919.1. NC_011229.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 412419.BDU_261.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH93213 ; ACH93213 ; BDU_261 .
GeneIDi 6918345.
KEGGi bdu:BDU_261.
PATRICi 20562628. VBIBorDut9941_0287.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi PIVFDIY.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BDUT412419:GJ78-261-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
    Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
    PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ly.

Entry informationi

Entry nameiUPPP_BORDL
AccessioniPrimary (citable) accession number: B5RL84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi