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B5RL76

- SYL_BORDL

UniProt

B5RL76 - SYL_BORDL

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia duttonii (strain Ly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBDUT412419:GJ78-253-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BDU_253
    OrganismiBorrelia duttonii (strain Ly)
    Taxonomic identifieri412419 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeBorrelia
    ProteomesiUP000000611: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 842842Leucine--tRNA ligasePRO_1000091292Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi412419.BDU_253.

    Structurei

    3D structure databases

    ProteinModelPortaliB5RL76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi44 – 5512"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiERYWMNV.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5RL76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKYDFKKIE KKWQNYWDKH KTYKVNEDPN VPKEKRIYIL DMFPYPSANG    50
    LHVGHPEGYT ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGKHP 100
    KKITEKNIEK FKEQIKALGF AYDWDREIKT HDVNYYKWTQ WIFLQLYKKG 150
    LAYTKEIPVW YCPDLGTVLA NEEVIQTPDG PRSERGFHKV ERKPLRQWLL 200
    KITKYAERLI RDLEEVDWPD SVKEMQKNWI GKSTGVEIEF LIKESKEKIK 250
    VFTTRPDTIF GVTYLVLAPE HPMVDKITKD ELKPIISKYK DKEILKSDLE 300
    RTSLEKDKTG IFTGAYAINP ITKEEIPIWI GSYILGTYGT GAVMSVPAHD 350
    ERDFEFAKKY NLPIKQVVSQ TGTNEVLIKP FTENGISINT PTEFNNLKTI 400
    EVKTKVIKWL IENKMGQEKV NYKLRDWIFS RQRYWGEPIP ILFDDNLNEI 450
    PLNDDELPLT LPDIENYKPS GTGESPLSKI KDWVNVKRNG KIYKRETNTM 500
    PQWAGSCWYY IRYLDPHNKK EFANKEKINY WMPVDLYIGG AEHSVLHLLY 550
    ARFWHKVLYD LGYVNTKEPF RKLINQGMIT SFAYQDENGI LIPNDEVEKK 600
    DNKFFSKKNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG 650
    PLTDSKPWNT QGLIGIFRFL NKIWLIKNKE LTNETPPKEI ISELHKTIKK 700
    VTEDIETLNF NTAISTLMIF INELLKHEKN YLKIFRPISI ILSPFAPHLG 750
    EELWEFMGEQ SSIFKNAKWP KYDLNSIIDD TREIVLQVNG KTKDKIMIKK 800
    DTDEETLKKI AFNNQKIIQN INNKQIIKII TVKDKLVNIV AK 842
    Length:842
    Mass (Da):98,696
    Last modified:November 4, 2008 - v1
    Checksum:i35F1575144D23FA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000976 Genomic DNA. Translation: ACH93205.1.
    RefSeqiYP_002221911.1. NC_011229.1.

    Genome annotation databases

    EnsemblBacteriaiACH93205; ACH93205; BDU_253.
    GeneIDi6918337.
    KEGGibdu:BDU_253.
    PATRICi20562612. VBIBorDut9941_0279.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000976 Genomic DNA. Translation: ACH93205.1 .
    RefSeqi YP_002221911.1. NC_011229.1.

    3D structure databases

    ProteinModelPortali B5RL76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412419.BDU_253.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH93205 ; ACH93205 ; BDU_253 .
    GeneIDi 6918337.
    KEGGi bdu:BDU_253.
    PATRICi 20562612. VBIBorDut9941_0279.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi ERYWMNV.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci BDUT412419:GJ78-253-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
      Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
      PLoS Genet. 4:E1000185-E1000185(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ly.

    Entry informationi

    Entry nameiSYL_BORDL
    AccessioniPrimary (citable) accession number: B5RL76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3