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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Borrelia duttonii (strain Ly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei622ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BDU_253
OrganismiBorrelia duttonii (strain Ly)
Taxonomic identifieri412419 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesBorreliaceaeBorrelia
Proteomesi
  • UP000000611 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000912921 – 842Leucine--tRNA ligaseAdd BLAST842

Proteomic databases

PRIDEiB5RL76

Interactioni

Protein-protein interaction databases

STRINGi412419.BDU_253

Structurei

3D structure databases

ProteinModelPortaliB5RL76
SMRiB5RL76
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 55"HIGH" regionAdd BLAST12
Motifi619 – 623"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B5RL76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKYDFKKIE KKWQNYWDKH KTYKVNEDPN VPKEKRIYIL DMFPYPSANG
60 70 80 90 100
LHVGHPEGYT ATDILTRYKL LNGFNVLHPM GFDSFGLPAE NYAIQTGKHP
110 120 130 140 150
KKITEKNIEK FKEQIKALGF AYDWDREIKT HDVNYYKWTQ WIFLQLYKKG
160 170 180 190 200
LAYTKEIPVW YCPDLGTVLA NEEVIQTPDG PRSERGFHKV ERKPLRQWLL
210 220 230 240 250
KITKYAERLI RDLEEVDWPD SVKEMQKNWI GKSTGVEIEF LIKESKEKIK
260 270 280 290 300
VFTTRPDTIF GVTYLVLAPE HPMVDKITKD ELKPIISKYK DKEILKSDLE
310 320 330 340 350
RTSLEKDKTG IFTGAYAINP ITKEEIPIWI GSYILGTYGT GAVMSVPAHD
360 370 380 390 400
ERDFEFAKKY NLPIKQVVSQ TGTNEVLIKP FTENGISINT PTEFNNLKTI
410 420 430 440 450
EVKTKVIKWL IENKMGQEKV NYKLRDWIFS RQRYWGEPIP ILFDDNLNEI
460 470 480 490 500
PLNDDELPLT LPDIENYKPS GTGESPLSKI KDWVNVKRNG KIYKRETNTM
510 520 530 540 550
PQWAGSCWYY IRYLDPHNKK EFANKEKINY WMPVDLYIGG AEHSVLHLLY
560 570 580 590 600
ARFWHKVLYD LGYVNTKEPF RKLINQGMIT SFAYQDENGI LIPNDEVEKK
610 620 630 640 650
DNKFFSKKNN KELKQIIAKM SKSLKNIINP DDIIKEYGAD SMRIYEMFMG
660 670 680 690 700
PLTDSKPWNT QGLIGIFRFL NKIWLIKNKE LTNETPPKEI ISELHKTIKK
710 720 730 740 750
VTEDIETLNF NTAISTLMIF INELLKHEKN YLKIFRPISI ILSPFAPHLG
760 770 780 790 800
EELWEFMGEQ SSIFKNAKWP KYDLNSIIDD TREIVLQVNG KTKDKIMIKK
810 820 830 840
DTDEETLKKI AFNNQKIIQN INNKQIIKII TVKDKLVNIV AK
Length:842
Mass (Da):98,696
Last modified:November 4, 2008 - v1
Checksum:i35F1575144D23FA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000976 Genomic DNA Translation: ACH93205.1
RefSeqiWP_012538017.1, NC_011229.1

Genome annotation databases

EnsemblBacteriaiACH93205; ACH93205; BDU_253
KEGGibdu:BDU_253

Similar proteinsi

Entry informationi

Entry nameiSYL_BORDL
AccessioniPrimary (citable) accession number: B5RL76
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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