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Reviewed, UniProtKB/Swiss-Prot B5RL65 (GLPK_BORDL)

Last modified November 3, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol kinase
    EC=2.7.1.30
Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Glycerokinase
      Short name=GK
Gene names
Name: glpK
Ordered Locus Names: BDU_241
OrganismBorrelia duttonii (strain Ly) [Complete proteome] [HAMAP]
Taxonomic identifier412419 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Spirochaetaceae › Borrelia

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Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity.

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

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Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionATP binding

Inferred from electronic annotation. Source: HAMAP

glycerol kinase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 496496Glycerol kinase HAMAP MF_00186
PRO_1000098717

Regions

Nucleotide binding409 – 4135ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

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Sequences

Sequence LengthMass (Da)Tools
B5RL65-1 [UniParc].

Last modified November 4, 2008. Version 1.
Checksum: 275AD9B1A2661CC8

FASTA49655,930
        10         20         30         40         50         60 
MKYILSIDQG TTSSRAIIFD RNANIKGFAQ KDFKQIYPHP SWVEHNPNEI WSSLLEIISE 

        70         80         90        100        110        120 
ALANARTHPN EIATIGITNQ RETTIIWDRY TGQPIYNAIV WQDRRTAKIC DELKTQGKDK 

       130        140        150        160        170        180 
IFLEKTGLVL DPYFSGTKIK WILDNVSQAR ERAEKGELCF GTIDTWIIWN LTKGKIHITD 

       190        200        210        220        230        240 
YSNASRTLLL NINSLNWDDD LLQILNIPKS ILPELKQSSE IYGKIDSSIM GTEINISGIA 

       250        260        270        280        290        300 
GDQFAATFGQ SCLQKGMAKN TYGTGCFTTV NIGHKPIINE QKILTSIAWV KKNITTYVFE 

       310        320        330        340        350        360 
GSIFIGGAVI QWLRDNLELF KKSSDAEILA ASVNNNGGIY FVPAFVGLGT PHWDPYARGT 

       370        380        390        400        410        420 
IIGLTRSSTK EHITRAALES IAFQSFDVLT EMKNSIKGFD IKELRVDGKA SQNNLLMQFQ 

       430        440        450        460        470        480 
ADILQCNVVR PKITETTALG AAYLAGLAIG YWENTEEITS LWKSDKIFEP LMKQSQREDL 

       490 
IYNWHKAINR AKSWIE

« Hide

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References

[1]"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii."
Lescot M., Audic S., Robert C., Nguyen T.T., Blanc G., Cutler S.J., Wincker P., Couloux A., Claverie J.-M., Raoult D., Drancourt M.
PLoS Genet. 4:E1000185-E1000185(2008) [PubMed: 18787695] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000976 Genomic DNA. Translation: ACH93194.1.
RefSeqYP_002221900.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6918325.
GenomeReviewsGene locus BDU_241 in contig CP000976_GR.
KEGGbdu:BDU_241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAIAQREFT.

Family and domain databases

HAMAPMF_00186.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGLPK_BORDL
AccessionPrimary (citable) accession number: B5RL65
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: November 3, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents