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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

Gpdh1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei155NAD; via amide nitrogenUniRule annotation1
Active sitei206Proton acceptorUniRule annotation1
Binding sitei270NADUniRule annotation1
Binding sitei297NAD; via amide nitrogenUniRule annotation1
Binding sitei299NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
Name:Gpdh1Imported
Synonyms:alpha-GPDImported, alpha-GPDHImported, alpha-GpdhImported, alpha-GPDH-1Imported, alphaGpdImported, alphaGPDHImported, alphaGpdhImported, alphaGpdh-1Imported, dGpdhImported, Dmel\CG9042Imported, DmG3PDHImported, DROGPDHAImported, G3PDHImported, G3pdhImported, GAPDHImported, GdhImported, GPDImported, GpdImported, GPDAImported, GPDHImported, GpdhImported, gpdhImported, GPDH-1Imported, gpdh-1Imported, sn-GpdhImported
ORF Names:CG9042Imported, Dmel_CG9042Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001128 Gpdh1

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0001128

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 174NAD_Gly3P_dh_NInterPro annotationAdd BLAST169
Domaini195 – 340NAD_Gly3P_dh_CInterPro annotationAdd BLAST146

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni270 – 271Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
KOiK00006
OrthoDBiEOG091G0DO6

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

B5RIM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKVNVCIV GSGNWGSAIA KIVGANAAAL PEFEERVTMF VYEELIDGKK
60 70 80 90 100
LTEIINETHE NVKYLKGHKL PPNVVAVPDL VEAAKNADIL IFVVPHQFIP
110 120 130 140 150
NFCKQLLGKI KPNAIAISLI KGFDKAEGGG IDLISHIITR HLKIPCAVLM
160 170 180 190 200
GANLANEVAE GNFCETTIGC TDKKYGKVLR DLFQANHFRV VVVDDADAVE
210 220 230 240 250
VCGALKNIVA CGAGFVDGLK LGDNTKAAVI RLGLMEMIRF VDVFYPGSKL
260 270 280 290 300
STFFESCGVA DLITTCYGGR NRRVSEAFVT SGKTIEELEK EMLNGQKLQG
310 320 330 340 350
PPTAEEVNYM LKNKGLEDKF PLFTAIHKIC TNQLKPNDLI DCIRNHPEHM
360
DTSIMPSPKL
Length:360
Mass (Da):39,329
Last modified:November 4, 2008 - v1
Checksum:i7E7FB6FDF432CDD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT044153 mRNA Translation: ACH92218.1
AE014134 Genomic DNA Translation: AGB92648.1
RefSeqiNP_001260112.1, NM_001273183.2
NP_476565.1, NM_057217.4
UniGeneiDm.4843

Genome annotation databases

EnsemblMetazoaiFBtr0079146; FBpp0078777; FBgn0001128
FBtr0333229; FBpp0305431; FBgn0001128
GeneIDi33824
KEGGidme:Dmel_CG9042

Similar proteinsi

Entry informationi

Entry nameiB5RIM9_DROME
AccessioniPrimary (citable) accession number: B5RIM9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 4, 2008
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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