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B5RH48

- FMT_SALG2

UniProt

B5RH48 - FMT_SALG2

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Protein

Methionyl-tRNA formyltransferase

Gene
fmt, SG4031
Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP By similarity.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

  1. methionyl-tRNA formyltransferase activity Source: UniProtKB-HAMAP
  2. methyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Protein biosynthesis

Enzyme and pathway databases

BioCyciSENT550538:GJ93-3979-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferase (EC:2.1.2.9)
Gene namesi
Name:fmt
Ordered Locus Names:SG4031
OrganismiSalmonella gallinarum (strain 287/91 / NCTC 13346)
Taxonomic identifieri550538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008321: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Methionyl-tRNA formyltransferaseUniRule annotationPRO_1000098438Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi550538.SG4031.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni113 – 1164Tetrahydrofolate (THF) binding By similarity

Sequence similaritiesi

Belongs to the Fmt family.

Phylogenomic databases

eggNOGiCOG0223.
HOGENOMiHOG000261177.
OMAiRGDWFTP.
OrthoDBiEOG6B09WV.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans.
InterProiIPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view]
PANTHERiPTHR11138. PTHR11138. 1 hit.
PfamiPF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view]
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiPS00373. GART. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5RH48-1 [UniParc]FASTAAdd to Basket

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MSDSLRIIFA GTPDFAARHL DALLTSGHNV VGVFTQPDRP AGRGKKLMPS    50
PVKVLAEEKG LPVFQPVSLR PQENQQLVAD LHADVMVVVA YGLILPKAVL 100
DMPRLGCINV HGSLLPRWRG AAPIQRSLWA GDAETGVTIM QMDVGLDTGD 150
MLYKLACPIT AEDTSGSLYN KLAELGPQGL ITTLKQLADG TAAPEAQNEA 200
LVTHAEKLSK EEARIDWSLS AVQLERCIRA FNPWPMSWLE IDGQPVKVWQ 250
ASVIEDATQS LPGTILAATK QGIQVATGKG ILNLLSLQPA GKKAMSAQDL 300
LNSRREWFIP GNHLA 315
Length:315
Mass (Da):33,999
Last modified:November 4, 2008 - v1
Checksum:i4202147C1C20BBB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933173 Genomic DNA. Translation: CAR39802.1.
RefSeqiYP_002228766.1. NC_011274.1.

Genome annotation databases

EnsemblBacteriaiCAR39802; CAR39802; EBG00000233677.
PATRICi18506844. VBISalEnt1629_4280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933173 Genomic DNA. Translation: CAR39802.1 .
RefSeqi YP_002228766.1. NC_011274.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 550538.SG4031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR39802 ; CAR39802 ; EBG00000233677 .
PATRICi 18506844. VBISalEnt1629_4280.

Phylogenomic databases

eggNOGi COG0223.
HOGENOMi HOG000261177.
OMAi RGDWFTP.
OrthoDBi EOG6B09WV.

Enzyme and pathway databases

BioCyci SENT550538:GJ93-3979-MONOMER.

Family and domain databases

Gene3Di 3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPi MF_00182. Formyl_trans.
InterProi IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
IPR015518. Met_tRNA_Form_TA-like.
[Graphical view ]
PANTHERi PTHR11138. PTHR11138. 1 hit.
Pfami PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsi TIGR00460. fmt. 1 hit.
PROSITEi PS00373. GART. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 287/91 / NCTC 13346.

Entry informationi

Entry nameiFMT_SALG2
AccessioniPrimary (citable) accession number: B5RH48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: November 4, 2008
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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