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Protein

UDP-N-acetyl-D-mannosaminuronic acid transferase

Gene

wecG

Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-mannosaminouronate + N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = UDP + N-acetyl-beta-D-mannosaminouronyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol.UniRule annotation

Pathwayi: enterobacterial common antigen biosynthesis

This protein is involved in the pathway enterobacterial common antigen biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway enterobacterial common antigen biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00566.

Protein family/group databases

CAZyiGT26. Glycosyltransferase Family 26.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetyl-D-mannosaminuronic acid transferaseUniRule annotation (EC:2.4.1.180UniRule annotation)
Short name:
UDP-ManNAcA transferaseUniRule annotation
Gene namesi
Name:wecGUniRule annotation
Synonyms:rffMUniRule annotation
Ordered Locus Names:SG3514
OrganismiSalmonella gallinarum (strain 287/91 / NCTC 13346)
Taxonomic identifieri550538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000008321 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001345851 – 246UDP-N-acetyl-D-mannosaminuronic acid transferaseAdd BLAST246

Structurei

3D structure databases

SMRiB5RFQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 26 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000075380.
KOiK02852.
OMAiNMNGTDF.
OrthoDBiPOG091H00MT.

Family and domain databases

CDDicd06533. Glyco_transf_WecG_TagA. 1 hit.
HAMAPiMF_01001. WecG_RffM. 1 hit.
InterProiView protein in InterPro
IPR023085. UDP-ManNAcA_Trfase_WecG.
IPR004629. WecB_TagA_CpsF.
PANTHERiPTHR34136. PTHR34136. 1 hit.
PfamiView protein in Pfam
PF03808. Glyco_tran_WecB. 1 hit.
TIGRFAMsiTIGR00696. wecG_tagA_cpsF. 1 hit.

Sequencei

Sequence statusi: Complete.

B5RFQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNNAAAPLY SLRGLPLIGW RDMSHALNYL FADGQLKQGT LVAINAEKLL
60 70 80 90 100
TAEDNPEVRA LIAAAEFKYA DGISVVRSIR KKFPQAQVSR VAGADLWEAL
110 120 130 140 150
MARAGKEGTP VFLVGGKPEV LAQTEAKLRT QWNVNIVGSQ DGYFTPEQRQ
160 170 180 190 200
ALFARIHASG AKIVTVAMGS PKQELLMRDC REVHPHALYM GVGGTYDVFT
210 220 230 240
GHVKRAPKIW QNLGLEWLYR LLSQPRRITR QMRLLRYLRW HYTGDL
Length:246
Mass (Da):27,599
Last modified:November 4, 2008 - v1
Checksum:i847009586988CF0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM933173 Genomic DNA. Translation: CAR39303.1.
RefSeqiWP_000183621.1. NC_011274.1.

Genome annotation databases

KEGGiseg:SG3514.

Similar proteinsi

Entry informationi

Entry nameiWECG_SALG2
AccessioniPrimary (citable) accession number: B5RFQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome