ID   B5RBA1_SALG2            Unreviewed;       334 AA.
AC   B5RBA1;
DT   04-NOV-2008, integrated into UniProtKB/TrEMBL.
DT   04-NOV-2008, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=DNA polymerase III subunit delta' {ECO:0000256|ARBA:ARBA00014363};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN   Name=holB {ECO:0000313|EMBL:CAR37772.1};
GN   OrderedLocusNames=SG1921 {ECO:0000313|EMBL:CAR37772.1};
OS   Salmonella gallinarum (strain 287/91 / NCTC 13346).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=550538 {ECO:0000313|EMBL:CAR37772.1, ECO:0000313|Proteomes:UP000008321};
RN   [1] {ECO:0000313|EMBL:CAR37772.1, ECO:0000313|Proteomes:UP000008321}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=287/91 / NCTC 13346 {ECO:0000313|Proteomes:UP000008321};
RX   PubMed=18583645; DOI=10.1101/gr.077404.108;
RA   Thomson N.R., Clayton D.J., Windhorst D., Vernikos G., Davidson S.,
RA   Churcher C., Quail M.A., Stevens M., Jones M.A., Watson M., Barron A.,
RA   Layton A., Pickard D., Kingsley R.A., Bignell A., Clark L., Harris B.,
RA   Ormond D., Abdellah Z., Brooks K., Cherevach I., Chillingworth T.,
RA   Woodward J., Norberczak H., Lord A., Arrowsmith C., Jagels K., Moule S.,
RA   Mungall K., Sanders M., Whitehead S., Chabalgoity J.A., Maskell D.,
RA   Humphrey T., Roberts M., Barrow P.A., Dougan G., Parkhill J.;
RT   "Comparative genome analysis of Salmonella enteritidis PT4 and Salmonella
RT   gallinarum 287/91 provides insights into evolutionary and host adaptation
RT   pathways.";
RL   Genome Res. 18:1624-1637(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632};
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DR   EMBL; AM933173; CAR37772.1; -; Genomic_DNA.
DR   RefSeq; WP_000872468.1; NC_011274.1.
DR   AlphaFoldDB; B5RBA1; -.
DR   KEGG; seg:SG1921; -.
DR   HOGENOM; CLU_006229_4_3_6; -.
DR   Proteomes; UP000008321; Chromosome.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.272.10; -; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR004622; DNA_pol_HolB.
DR   InterPro; IPR015199; DNA_pol_III_delta_C.
DR   InterPro; IPR048731; HolB_lid-gammaproteobact.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00678; holB; 1.
DR   PANTHER; PTHR11669:SF8; DNA POLYMERASE III SUBUNIT DELTA; 1.
DR   PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR   Pfam; PF13177; DNA_pol3_delta2; 1.
DR   Pfam; PF09115; DNApol3-delta_C; 1.
DR   Pfam; PF21500; HolB_lid; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE   4: Predicted;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          167..206
FT                   /note="DNA polymerase III subunit delta' AAA+ ATPase lid"
FT                   /evidence="ECO:0000259|Pfam:PF21500"
FT   DOMAIN          208..320
FT                   /note="DNA polymerase III delta subunit C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF09115"
SQ   SEQUENCE   334 AA;  36851 MW;  BFCB7114CAF0F822 CRC64;
     MKWYSWLRPA YEKLVESYQA GRGHHALLIQ ALPGMGDEAL CYALSRYLLC QQPEGHKSCG
     HCRGCQLMQA GTHPDYYTLM PDKGKSSLGV DAVREVSEKL YEHSRLGGAK VVWIADAALL
     TDAAANALLK TLEEPPEQTW FFLASPEPAR LLATLRSRCR LHHLAAPSES YAMSWLSREV
     TASQEALLTA LRLNAGSPGA ALALLQSERW AQREALCQAL MDSLHTGDWY ALLTALNHEQ
     APARLHWLAT LLVDALKRQH GASYLTNVDA DAVVAALAGP LSPARIQAIL NDVCHCRDQL
     LHVTGLNREL VLTDLILRIE HYLQPGTLLP VPHL
//