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Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Salmonella gallinarum (strain 287/91 / NCTC 13346)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei11 – 111NucleophileUniRule annotation
Metal bindingi11 – 111MagnesiumUniRule annotation
Metal bindingi13 – 131Magnesium; via carbonyl oxygenUniRule annotation
Active sitei53 – 531Schiff-base intermediate with substrateUniRule annotation
Metal bindingi187 – 1871MagnesiumUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. organic phosphonate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding, Schiff base

Enzyme and pathway databases

BioCyciSENT550538:GJ93-440-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
Short name:
PhosphonataseUniRule annotation
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
Gene namesi
Name:phnXUniRule annotation
Ordered Locus Names:SG0443
OrganismiSalmonella gallinarum (strain 287/91 / NCTC 13346)
Taxonomic identifieri550538 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008321 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Phosphonoacetaldehyde hydrolasePRO_1000144839Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi550538.SG0443.

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000049554.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.

Sequencei

Sequence statusi: Complete.

B5R6T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNRIHAVIL DWAGTTVDFG SFAPTQIFVE AFRQAFDVEI TLAEARVPMG
60 70 80 90 100
LGKWQHIEAL GKLPAVDARW QAKFGRSMSA ADIDAIYAAF MPLQIAKVVD
110 120 130 140 150
FSSPIAGVID TIAALRAEGI KIGSCSGYPR AVMERLVPAA AEHGYRPDHW
160 170 180 190 200
VATDDLAAGG RPGPWMALQN VIALGIDAVA HCVKVDDAAL GISEGLNAGM
210 220 230 240 250
WTVGLAVSGN EFGATWDAYQ TMSKEDVAVR REHAASKLYA AGAHYVVDSL
260 270
ADLSGVIAHI NARLAQGERP
Length:270
Mass (Da):28,783
Last modified:November 4, 2008 - v1
Checksum:i14FC0778071D940E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM933173 Genomic DNA. Translation: CAR36342.1.
RefSeqiWP_000981894.1. NC_011274.1.
YP_002225544.1. NC_011274.1.

Genome annotation databases

EnsemblBacteriaiCAR36342; CAR36342; EBG00000234412.
PATRICi18499055. VBISalEnt1629_0480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM933173 Genomic DNA. Translation: CAR36342.1.
RefSeqiWP_000981894.1. NC_011274.1.
YP_002225544.1. NC_011274.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi550538.SG0443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR36342; CAR36342; EBG00000234412.
PATRICi18499055. VBISalEnt1629_0480.

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000049554.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Enzyme and pathway databases

BioCyciSENT550538:GJ93-440-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 287/91 / NCTC 13346.

Entry informationi

Entry nameiPHNX_SALG2
AccessioniPrimary (citable) accession number: B5R6T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: April 1, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.