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B5R6T3 (PHNX_SALG2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphonoacetaldehyde hydrolase

Short name=Phosphonatase
EC=3.11.1.1
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolase
Gene names
Name:phnX
Ordered Locus Names:SG0443
OrganismSalmonella gallinarum (strain 287/91 / NCTC 13346) [Complete proteome] [HAMAP]
Taxonomic identifier550538 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in phosphonate degradation By similarity. HAMAP-Rule MF_01375

Catalytic activity

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate. HAMAP-Rule MF_01375

Cofactor

Binds 1 Mg2+ ion per subunit By similarity. HAMAP-Rule MF_01375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01375

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PhnX family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
Schiff base
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processorganic phosphonate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphonoacetaldehyde hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Phosphonoacetaldehyde hydrolase HAMAP-Rule MF_01375
PRO_1000144839

Sites

Active site111Nucleophile By similarity
Active site531Schiff-base intermediate with substrate By similarity
Metal binding111Magnesium By similarity
Metal binding131Magnesium; via carbonyl oxygen By similarity
Metal binding1871Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B5R6T3 [UniParc].

Last modified November 4, 2008. Version 1.
Checksum: 14FC0778071D940E

FASTA27028,783
        10         20         30         40         50         60 
MMNRIHAVIL DWAGTTVDFG SFAPTQIFVE AFRQAFDVEI TLAEARVPMG LGKWQHIEAL 

        70         80         90        100        110        120 
GKLPAVDARW QAKFGRSMSA ADIDAIYAAF MPLQIAKVVD FSSPIAGVID TIAALRAEGI 

       130        140        150        160        170        180 
KIGSCSGYPR AVMERLVPAA AEHGYRPDHW VATDDLAAGG RPGPWMALQN VIALGIDAVA 

       190        200        210        220        230        240 
HCVKVDDAAL GISEGLNAGM WTVGLAVSGN EFGATWDAYQ TMSKEDVAVR REHAASKLYA 

       250        260        270 
AGAHYVVDSL ADLSGVIAHI NARLAQGERP 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM933173 Genomic DNA. Translation: CAR36342.1.
RefSeqYP_002225544.1. NC_011274.1.

3D structure databases

ProteinModelPortalB5R6T3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING550538.SG0443.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC18499055. VBISalEnt1629_0480.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0637.
HOGENOMHOG000049554.
OMAFDWAGTM.
OrthoDBEOG6ZH2FH.
ProtClustDBPRK13478.

Enzyme and pathway databases

BioCycSENT550538:GJ93-440-MONOMER.

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPMF_01375. PhnX.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01509. HAD-SF-IA-v3. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHNX_SALG2
AccessionPrimary (citable) accession number: B5R6T3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families