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B5R421

- LPXB_SALEP

UniProt

B5R421 - LPXB_SALEP

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, SEN0236
Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSENT550537:GJFI-232-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:SEN0236
OrganismiSalmonella enteritidis PT4 (strain P125109)
Taxonomic identifieri550537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000613: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 382382Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000123059Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi550537.SEN0236.

Structurei

3D structure databases

ProteinModelPortaliB5R421.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B5R421-1 [UniParc]FASTAAdd to Basket

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MAAQRPLTIA LVAGETSGDI LGAGLIRALK ARVPNARFVG VAGPRMQAEG    50
CEAWYEMEEL AVMGIVEVLG RLRRLLHIRA DLTRRFTELK PDVFVGIDAP 100
DFNITLEGNL KKQGIKTIHY VSPSVWAWRQ KRVFKIGRST HMVLAFLPFE 150
KAFYDKFNVP CRFIGHTMAD AMPLDPDKNA ARDVLGIPHD AHCLALLPGS 200
RGAEVEMLSA DFLKTAQLLR QRYPDLEVVV PLVNAKRREQ FEKIKAEVAP 250
DLAVHLLDGM AREAMIASDA ALLASGTAAL ECMLAKCPMV VGYRMKPFTF 300
WLAKRLVKTE YVSLPNLLAG RELVKELLQE ECEPQKLAEA LLPLLANGKT 350
SHAMHDTFRE LHQQIRCNAD EQAADAVLEL AQ 382
Length:382
Mass (Da):42,452
Last modified:November 4, 2008 - v1
Checksum:iD844CCF247939FE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR31824.1.
RefSeqiYP_002242398.1. NC_011294.1.

Genome annotation databases

EnsemblBacteriaiCAR31824; CAR31824; SEN0236.
PATRICi32330849. VBISalEnt14964_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR31824.1 .
RefSeqi YP_002242398.1. NC_011294.1.

3D structure databases

ProteinModelPortali B5R421.
ModBasei Search...

Protein-protein interaction databases

STRINGi 550537.SEN0236.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR31824 ; CAR31824 ; SEN0236 .
PATRICi 32330849. VBISalEnt14964_0236.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SENT550537:GJFI-232-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P125109.

Entry informationi

Entry nameiLPXB_SALEP
AccessioniPrimary (citable) accession number: B5R421
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: June 11, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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