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B5R1K2

- AMPA_SALEP

UniProt

B5R1K2 - AMPA_SALEP

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Protein
Probable cytosol aminopeptidase
Gene
pepA, SEN4230
Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity.UniRule annotation

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotation
Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.

Cofactori

Binds 2 manganese ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi270 – 2701Manganese 2 By similarity
Metal bindingi275 – 2751Manganese 1 By similarity
Metal bindingi275 – 2751Manganese 2 By similarity
Active sitei282 – 2821 Reviewed prediction
Metal bindingi293 – 2931Manganese 2 By similarity
Metal bindingi352 – 3521Manganese 1 By similarity
Metal bindingi354 – 3541Manganese 1 By similarity
Metal bindingi354 – 3541Manganese 2 By similarity
Active sitei356 – 3561 Reviewed prediction

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. metalloexopeptidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSENT550537:GJFI-4292-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidase (EC:3.4.11.1)
    Alternative name(s):
    Leucine aminopeptidase (EC:3.4.11.10)
    Short name:
    LAP
    Leucyl aminopeptidase
    Gene namesi
    Name:pepA
    Ordered Locus Names:SEN4230
    OrganismiSalmonella enteritidis PT4 (strain P125109)
    Taxonomic identifieri550537 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000613: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Probable cytosol aminopeptidaseUniRule annotation
    PRO_1000098345Add
    BLAST

    Proteomic databases

    PRIDEiB5R1K2.

    Interactioni

    Protein-protein interaction databases

    STRINGi550537.SEN4230.

    Structurei

    3D structure databases

    ProteinModelPortaliB5R1K2.
    SMRiB5R1K2. Positions 1-503.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243132.
    OMAiANEAKMS.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5R1K2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSVKSGSP EKQRSACIVV GVFEPRRLSP IAEQLDKISD GYISALLRRG    50
    ELEGKPGQTL LLHHVPNVLS ERILLIGCGK ERELDERQYK QVIQKTINTL 100
    NDTGSMEAVC FLTELHVKGR NNYWKVRQAV ETAKETLYSF DQLKTNKSEP 150
    RRPLRKMVFN VPTRRELTSG ERAIQHGLAI AAGIKAAKDL GNMPPNICNA 200
    AYLASQARQL ADSYSKNVIT RVIGEQQMRE LGMNAYLAVG HGSQNESLMS 250
    VIEYKGNPSE DARPIVLVGK GLTFDSGGIS IKPSEGMDEM KYDMCGAAAV 300
    YGVMRMVAEL QLPINVIGVL AGCENMPGGR AYRPGDVLTT MSGQTVEVLN 350
    TDAEGRLVLC DVLTYVERFE PEAVIDVATL TGACVIALGH HITGLMSNHN 400
    PLAHELIGAS EQAGDRAWRL PLGDEFQEQL ESNFADMANI GGRPGGAITA 450
    GCFLSRFTRK YNWAHLDIAG TAWRSGKAKG ATGRPVALLS QFLLNRAGFN 500
    GEE 503
    Length:503
    Mass (Da):54,890
    Last modified:November 4, 2008 - v1
    Checksum:i65649F32506FA00A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR35785.1.
    RefSeqiYP_002246254.1. NC_011294.1.

    Genome annotation databases

    EnsemblBacteriaiCAR35785; CAR35785; SEN4230.
    PATRICi32339187. VBISalEnt14964_4306.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR35785.1 .
    RefSeqi YP_002246254.1. NC_011294.1.

    3D structure databases

    ProteinModelPortali B5R1K2.
    SMRi B5R1K2. Positions 1-503.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 550537.SEN4230.

    Proteomic databases

    PRIDEi B5R1K2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR35785 ; CAR35785 ; SEN4230 .
    PATRICi 32339187. VBISalEnt14964_4306.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243132.
    OMAi ANEAKMS.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci SENT550537:GJFI-4292-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P125109.

    Entry informationi

    Entry nameiAMPA_SALEP
    AccessioniPrimary (citable) accession number: B5R1K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: November 4, 2008
    Last modified: June 11, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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