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B5QZD8

- PNCB_SALEP

UniProt

B5QZD8 - PNCB_SALEP

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Protein

Nicotinate phosphoribosyltransferase

Gene
pncB, SEN0908
Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciSENT550537:GJFI-920-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:SEN0908
OrganismiSalmonella enteritidis PT4 (strain P125109)
Taxonomic identifieri550537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000613: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Nicotinate phosphoribosyltransferaseUniRule annotationPRO_1000129484Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi550537.SEN0908.

Structurei

3D structure databases

ProteinModelPortaliB5QZD8.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B5QZD8-1 [UniParc]FASTAAdd to Basket

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MTQFASPVLH SLLDTDAYKL HMQQAVFHHY YDVQVAAEFR CRGDDLLGIY    50
ADAIREQVDA MQHLRLQEDE FQWLSGLPFF KPDYLNWLRE FRYNPAQVCV 100
TNDNGKLNIR LTGPWREVIM WEVPLLAVIS ELVHHYRSPN AGVDQALDAL 150
ESKLVDFTAL TANLDMSRFH LMDFGTRRRF SREVQQAIVK RLQQESWFVG 200
TSNYDLARRL ALTPMGTQAH EWFQAHQQIS PDLATSQRAA LAAWLNEYPD 250
QLGIALTDCI TMDAFLRDFG IEFASRYQGL RHDSGDPVAW GEKAIAHYEK 300
LGIDPLTKTL VFSDNLDLPK AVELYRHFAS RVQLSFGIGT RLTCDIPQVK 350
PLNIVIKLVE CNGKPVAKLS DSPGKTICHD KAFVRALRKA FDLPQVRKAS 400
Length:400
Mass (Da):45,676
Last modified:November 4, 2008 - v1
Checksum:i01BEF766F4D427F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR32491.1.
RefSeqiYP_002243046.1. NC_011294.1.

Genome annotation databases

EnsemblBacteriaiCAR32491; CAR32491; SEN0908.
PATRICi32332274. VBISalEnt14964_0926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR32491.1 .
RefSeqi YP_002243046.1. NC_011294.1.

3D structure databases

ProteinModelPortali B5QZD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 550537.SEN0908.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR32491 ; CAR32491 ; SEN0908 .
PATRICi 32332274. VBISalEnt14964_0926.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci SENT550537:GJFI-920-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P125109.

Entry informationi

Entry nameiPNCB_SALEP
AccessioniPrimary (citable) accession number: B5QZD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: November 4, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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