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B5QZ48

- MUG_SALEP

UniProt

B5QZ48 - MUG_SALEP

Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

    Catalytic activityi

    Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. DNA repair Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciSENT550537:GJFI-3095-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
    Alternative name(s):
    Double-strand-specific uracil glycosylaseUniRule annotation
    Mismatch-specific uracil DNA-glycosylaseUniRule annotation
    Short name:
    MUGUniRule annotation
    Gene namesi
    Name:mugUniRule annotation
    Ordered Locus Names:SEN3055
    OrganismiSalmonella enteritidis PT4 (strain P125109)
    Taxonomic identifieri550537 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000613: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 168168G/U mismatch-specific DNA glycosylasePRO_1000188964Add
    BLAST

    Proteomic databases

    PRIDEiB5QZ48.

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi550537.SEN3055.

    Structurei

    3D structure databases

    ProteinModelPortaliB5QZ48.
    SMRiB5QZ48. Positions 1-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TDG/mug DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3663.
    HOGENOMiHOG000264684.
    OMAiETGCGIT.
    OrthoDBiEOG68H872.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_01956. MUG.
    InterProiIPR023502. DNA_glyclase_G/T-mismatch_bac.
    IPR015637. DNA_glycosylase_G/T-mismatch.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR12159. PTHR12159. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5QZ48-1 [UniParc]FASTAAdd to Basket

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    MVKDILAPGL RVVFCGINPG LSSANTGFPF AHPANRFWKV IHLAGFTDRQ    50
    LKPEEAEKLL DFRCGVTKLV DRPTVQATEV KLHELRSGGR NLIEKIEDYQ 100
    PAALAVLGKQ AFEQGFSQRG IAWGKQKIAI GATMVWVLPN PSGLNRIKTE 150
    KLVEAYRELD QALIMRGL 168
    Length:168
    Mass (Da):18,650
    Last modified:November 4, 2008 - v1
    Checksum:iA946974A29B16FF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR34631.1.
    RefSeqiYP_002245121.1. NC_011294.1.

    Genome annotation databases

    EnsemblBacteriaiCAR34631; CAR34631; SEN3055.
    PATRICi32336718. VBISalEnt14964_3113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR34631.1 .
    RefSeqi YP_002245121.1. NC_011294.1.

    3D structure databases

    ProteinModelPortali B5QZ48.
    SMRi B5QZ48. Positions 1-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 550537.SEN3055.

    Proteomic databases

    PRIDEi B5QZ48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR34631 ; CAR34631 ; SEN3055 .
    PATRICi 32336718. VBISalEnt14964_3113.

    Phylogenomic databases

    eggNOGi COG3663.
    HOGENOMi HOG000264684.
    OMAi ETGCGIT.
    OrthoDBi EOG68H872.

    Enzyme and pathway databases

    BioCyci SENT550537:GJFI-3095-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_01956. MUG.
    InterProi IPR023502. DNA_glyclase_G/T-mismatch_bac.
    IPR015637. DNA_glycosylase_G/T-mismatch.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR12159. PTHR12159. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P125109.

    Entry informationi

    Entry nameiMUG_SALEP
    AccessioniPrimary (citable) accession number: B5QZ48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3