SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B5QZ48

- MUG_SALEP

UniProt

B5QZ48 - MUG_SALEP

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
G/U mismatch-specific DNA glycosylase
Gene
mug, SEN3055
Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells By similarity.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: InterPro

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT550537:GJFI-3095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylase (EC:3.2.2.28)
Alternative name(s):
Double-strand-specific uracil glycosylase
Mismatch-specific uracil DNA-glycosylase
Short name:
MUG
Gene namesi
Name:mug
Ordered Locus Names:SEN3055
OrganismiSalmonella enteritidis PT4 (strain P125109)
Taxonomic identifieri550537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000613: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168G/U mismatch-specific DNA glycosylaseUniRule annotation
PRO_1000188964Add
BLAST

Proteomic databases

PRIDEiB5QZ48.

Interactioni

Subunit structurei

Binds DNA as a monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi550537.SEN3055.

Structurei

3D structure databases

ProteinModelPortaliB5QZ48.
SMRiB5QZ48. Positions 1-165.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3663.
HOGENOMiHOG000264684.
OMAiETGCGIT.
OrthoDBiEOG68H872.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR023502. DNA_glyclase_G/T-mismatch_bac.
IPR015637. DNA_glycosylase_G/T-mismatch.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.

Sequencei

Sequence statusi: Complete.

B5QZ48-1 [UniParc]FASTAAdd to Basket

« Hide

MVKDILAPGL RVVFCGINPG LSSANTGFPF AHPANRFWKV IHLAGFTDRQ    50
LKPEEAEKLL DFRCGVTKLV DRPTVQATEV KLHELRSGGR NLIEKIEDYQ 100
PAALAVLGKQ AFEQGFSQRG IAWGKQKIAI GATMVWVLPN PSGLNRIKTE 150
KLVEAYRELD QALIMRGL 168
Length:168
Mass (Da):18,650
Last modified:November 4, 2008 - v1
Checksum:iA946974A29B16FF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR34631.1.
RefSeqiYP_002245121.1. NC_011294.1.

Genome annotation databases

EnsemblBacteriaiCAR34631; CAR34631; SEN3055.
PATRICi32336718. VBISalEnt14964_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR34631.1 .
RefSeqi YP_002245121.1. NC_011294.1.

3D structure databases

ProteinModelPortali B5QZ48.
SMRi B5QZ48. Positions 1-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 550537.SEN3055.

Proteomic databases

PRIDEi B5QZ48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR34631 ; CAR34631 ; SEN3055 .
PATRICi 32336718. VBISalEnt14964_3113.

Phylogenomic databases

eggNOGi COG3663.
HOGENOMi HOG000264684.
OMAi ETGCGIT.
OrthoDBi EOG68H872.

Enzyme and pathway databases

BioCyci SENT550537:GJFI-3095-MONOMER.

Family and domain databases

Gene3Di 3.40.470.10. 1 hit.
HAMAPi MF_01956. MUG.
InterProi IPR023502. DNA_glyclase_G/T-mismatch_bac.
IPR015637. DNA_glycosylase_G/T-mismatch.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view ]
PANTHERi PTHR12159. PTHR12159. 1 hit.
Pfami PF03167. UDG. 1 hit.
[Graphical view ]
SMARTi SM00986. UDG. 1 hit.
[Graphical view ]
SUPFAMi SSF52141. SSF52141. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P125109.

Entry informationi

Entry nameiMUG_SALEP
AccessioniPrimary (citable) accession number: B5QZ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 4, 2008
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi