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B5QZ48

- MUG_SALEP

UniProt

B5QZ48 - MUG_SALEP

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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. hydrolase activity, hydrolyzing N-glycosyl compounds Source: InterPro

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA excision, DNA repair

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSENT550537:GJFI-3095-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:SEN3055
OrganismiSalmonella enteritidis PT4 (strain P125109)
Taxonomic identifieri550537 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000000613: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 168168G/U mismatch-specific DNA glycosylasePRO_1000188964Add
BLAST

Proteomic databases

PRIDEiB5QZ48.

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi550537.SEN3055.

Structurei

3D structure databases

ProteinModelPortaliB5QZ48.
SMRiB5QZ48. Positions 1-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TDG/mug DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3663.
HOGENOMiHOG000264684.
OMAiETGCGIT.
OrthoDBiEOG68H872.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG.
InterProiIPR023502. DNA_glyclase_G/T-mismatch_bac.
IPR015637. DNA_glycosylase_G/T-mismatch.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR12159. PTHR12159. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.

Sequencei

Sequence statusi: Complete.

B5QZ48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKDILAPGL RVVFCGINPG LSSANTGFPF AHPANRFWKV IHLAGFTDRQ
60 70 80 90 100
LKPEEAEKLL DFRCGVTKLV DRPTVQATEV KLHELRSGGR NLIEKIEDYQ
110 120 130 140 150
PAALAVLGKQ AFEQGFSQRG IAWGKQKIAI GATMVWVLPN PSGLNRIKTE
160
KLVEAYRELD QALIMRGL
Length:168
Mass (Da):18,650
Last modified:November 4, 2008 - v1
Checksum:iA946974A29B16FF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR34631.1.
RefSeqiYP_002245121.1. NC_011294.1.

Genome annotation databases

EnsemblBacteriaiCAR34631; CAR34631; SEN3055.
PATRICi32336718. VBISalEnt14964_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM933172 Genomic DNA. Translation: CAR34631.1 .
RefSeqi YP_002245121.1. NC_011294.1.

3D structure databases

ProteinModelPortali B5QZ48.
SMRi B5QZ48. Positions 1-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 550537.SEN3055.

Proteomic databases

PRIDEi B5QZ48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR34631 ; CAR34631 ; SEN3055 .
PATRICi 32336718. VBISalEnt14964_3113.

Phylogenomic databases

eggNOGi COG3663.
HOGENOMi HOG000264684.
OMAi ETGCGIT.
OrthoDBi EOG68H872.

Enzyme and pathway databases

BioCyci SENT550537:GJFI-3095-MONOMER.

Family and domain databases

Gene3Di 3.40.470.10. 1 hit.
HAMAPi MF_01956. MUG.
InterProi IPR023502. DNA_glyclase_G/T-mismatch_bac.
IPR015637. DNA_glycosylase_G/T-mismatch.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view ]
PANTHERi PTHR12159. PTHR12159. 1 hit.
Pfami PF03167. UDG. 1 hit.
[Graphical view ]
SMARTi SM00986. UDG. 1 hit.
[Graphical view ]
SUPFAMi SSF52141. SSF52141. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: P125109.

Entry informationi

Entry nameiMUG_SALEP
AccessioniPrimary (citable) accession number: B5QZ48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: November 4, 2008
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3