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B5QVH1

- GPPA_SALEP

UniProt

B5QVH1 - GPPA_SALEP

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Salmonella enteritidis PT4 (strain P125109)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciSENT550537:GJFI-3776-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:SEN3719
    OrganismiSalmonella enteritidis PT4 (strain P125109)
    Taxonomic identifieri550537 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000000613: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000192534Add
    BLAST

    Proteomic databases

    PRIDEiB5QVH1.

    Interactioni

    Protein-protein interaction databases

    STRINGi550537.SEN3719.

    Structurei

    3D structure databases

    ProteinModelPortaliB5QVH1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5QVH1-1 [UniParc]FASTAAdd to Basket

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    MNSTSLYAAI DLGSNSFHML VVREAAGSIQ TLTRIKRKVR LAAGLNNDNH    50
    LSAEAMERGW QCLRLFAERL QDIPQPQIRV VATATLRLAV NAGEFIAKAQ 100
    TILGCPVQVI SGEEEARLIY QGVAHTTGGA DQRLVVDIGG ASTELVTGTG 150
    AQTTSLFSLS MGCVTWLERY FSDRNLAQEN FDDAEKAARD VLRPVADELR 200
    FHGWKVCVGA SGTVQALQEI MMAQGMDERI TLAKLQQLKQ RAIQCGRLEE 250
    LEIEGLTLER ALVFPSGLAI LIAIFTELNI QSMTLAGGAL REGLVYGMLH 300
    LAVDQDIRSR TLRNIQRRFI VDTDQANRVA KLADNFLKQV ENAWHIEPIS 350
    RELLLSACQL HEIGLSVDFK QAPYHAAYLV RHLDLPGYTP AQKKLLATLL 400
    LNQTNPVDLS SLHQQNAVPP RVAEQLCRLL RLAILFAGRR RDDLVPEITL 450
    QALNENLTLT LPGDWLAHHP LGKELIDQES QWQSYVHWPL DVR 493
    Length:493
    Mass (Da):54,816
    Last modified:November 4, 2008 - v1
    Checksum:i992697E61F583EF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR35294.1.
    RefSeqiYP_002245776.1. NC_011294.1.

    Genome annotation databases

    EnsemblBacteriaiCAR35294; CAR35294; SEN3719.
    PATRICi32338116. VBISalEnt14964_3795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM933172 Genomic DNA. Translation: CAR35294.1 .
    RefSeqi YP_002245776.1. NC_011294.1.

    3D structure databases

    ProteinModelPortali B5QVH1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 550537.SEN3719.

    Proteomic databases

    PRIDEi B5QVH1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR35294 ; CAR35294 ; SEN3719 .
    PATRICi 32338116. VBISalEnt14964_3795.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci SENT550537:GJFI-3776-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: P125109.

    Entry informationi

    Entry nameiGPPA_SALEP
    AccessioniPrimary (citable) accession number: B5QVH1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3