B5P5Q0 (B5P5Q0_SALET) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase HAMAP MF_00596
EC=1.7.1.7 HAMAP MF_00596

Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_00596

Gene names

Name:	guaC HAMAP MF_00596
ORF Names:	SeHB_A0110 EMBL EDZ24240.1

Organism

Salmonella enterica subsp. enterica serovar Heidelberg str. SL486 EMBL EDZ24240.1

Taxonomic identifier

454164 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella enterica subsp. enterica serovar Heidelberg

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_00596
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. SAAS SAAS001093 HAMAP MF_00596
Subunit structure	Homotetramer By similarity. HAMAP MF_00596
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily. HAMAP MF_00596
Caution	The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Ontologies

Keywords
Ligand	Metal-binding SAAS SAAS005993 HAMAP MF_00596 NADP SAAS SAAS001093 HAMAP MF_00596 Potassium SAAS SAAS005993 HAMAP MF_00596
Molecular function	Oxidoreductase SAAS SAAS001093 HAMAP MF_00596 EMBL EDZ24240.1
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	108 – 131	24	NADP By similarity HAMAP MF_00596
	Nucleotide binding	216 – 239	24	NADP; ribose moiety By similarity HAMAP MF_00596
Sites
	Active site	186	1	Thioimidate intermediate By similarity HAMAP MF_00596
	Metal binding	181	1	Potassium; via carbonyl oxygen By similarity HAMAP MF_00596
	Metal binding	183	1	Potassium; via carbonyl oxygen By similarity HAMAP MF_00596

Sequences

	Sequence		Length	Mass (Da)
	B5P5Q0 [UniParc]. Last modified November 4, 2008. Version 1. Checksum: 71223D342F001B45	FASTA	347	37,139
	10 20 30 40 50 60 MRIEEDLKLG FKDVLIRPKR STLKSRSDVE LERQFTFKHS GQTWSGVPII AANMDTVGTF 70 80 90 100 110 120 EMAQALAGFD ILTAVHKHYT VEEWAAFINT ASADVLKHVM VSTGTSDADF EKTVQILALN 130 140 150 160 170 180 PALNFVCIDV ANGYSEHFVQ FVAKAREAWP TKTICAGNVV TGEMCEELIL SGADIVKVGI 190 200 210 220 230 240 GPGSVCTTRV KTGVGYPQLS AVIECADAAH GLGGMIVSDG GCTMPGDVAK AFGGGADFVM 250 260 270 280 290 300 LGGMLAGHEE SGGSVVEENG EKFMLFYGMS SESAMNRHVG GVAKYRAAEG KTVKLPLRGP 310 320 330 340 VGNTARDILG GLRSACTYVG ASRLKELTKR TTFIRVQEQE NRIFNSL

References

[1]	"Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution." Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A. J. Bacteriol. 193:3556-3568(2011) [PubMed: 21602358] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SL486 EMBL EDZ24240.1.
[2]	Rosovitz M.J., McDermott P., White D., LeClerc J.E., Mammel M.K., Cebula T.A., Ravel J. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SL486 EMBL EDZ24240.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABEL01000008 Genomic DNA. Translation: EDZ24240.1.
3D structure databases
ProteinModelPortal	B5P5Q0.
SMR	B5P5Q0. Positions 3-338.
ModBase	Search...
Proteomic databases
PRIDE	B5P5Q0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	27946681. VBISalEnt60298_3053.
Family and domain databases
HAMAP	MF_00596. GMP_reduct_type1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11911:SF33. PTHR11911:SF33. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5P5Q0_SALET

Accession

Primary (citable) accession number: B5P5Q0

Entry history

Integrated into UniProtKB/TrEMBL:	November 4, 2008
Last sequence update:	November 4, 2008
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)