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Protein

Olfactomedin-like protein 3

Gene

olfml3

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid protease BMP1 and its substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation by BMP1.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactomedin-like protein 3
Alternative name(s):
Olfactomedin-noelin-tiarin factor 1
Gene namesi
Name:olfml3
Synonyms:ont1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6022244. olfml3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 392373Olfactomedin-like protein 3PRO_0000361565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi132 ↔ 314PROSITE-ProRule annotation
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts (via coiled coil domain) with BMP1 and (via olfactomedin-like domain) CHRD.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1997734,EBI-1997734
bmp1P980703EBI-1997734,EBI-1997775
chrdQ917136EBI-1997734,EBI-1997746

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

IntActiB5MFE9. 4 interactions.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini131 – 387257Olfactomedin-likePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili52 – 10049Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the OLFML3 family.Curated
Contains 1 olfactomedin-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

HOVERGENiHBG108213.

Family and domain databases

InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR003112. Olfac-like_dom.
IPR031230. OLFML3.
[Graphical view]
PANTHERiPTHR23192:SF8. PTHR23192:SF8. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5MFE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAGIVACIL LVFVTVITAQ PQAVFLEYIQ GRMGVLEERI AQWHDQSSRF
60 70 80 90 100
SGELRDFKNQ VLKMLENIEK ERDSLRNEME NTNVRVNRLE REVDYIETQN
110 120 130 140 150
PAPPCVEIDE KLSDHHGAKK KKKEKYQKIT DCSDTISQVT AMKILKRFGS
160 170 180 190 200
SAGLWTKDLA GNSDRIYVFD GAGNDTVYMY PRMKEFTLSS PTRKAAKIRL
210 220 230 240 250
PFPWIGTGHI VYDGNLYYIR QDNEFQVIKF SLANKTIIDS AVLPIEQQVP
260 270 280 290 300
VYGLSKFNYI DIVADEEGLW VIYATKENEK NICLAKLDPS SLSIEQMWDT
310 320 330 340 350
PCPIENAESA FVVCGSLYVV YNTKLPSRSR IQCVFDVSGT ISSENVPIVY
360 370 380 390
FPKRYGSHSS MKYNPREKQI YAWDDGYQII YKLNMKHRDE LY
Length:392
Mass (Da):45,110
Last modified:January 20, 2009 - v2
Checksum:i14466FFBBD41A7A8
GO

Sequence cautioni

The sequence AAH84769 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti113 – 1131S → T in BAG71407 (PubMed:18775317).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB440138 mRNA. Translation: BAG71407.1.
BC084769 mRNA. Translation: AAH84769.1. Different initiation.
RefSeqiNP_001088445.1. NM_001094976.1.
UniGeneiXl.49181.

Genome annotation databases

GeneIDi495309.
KEGGixla:495309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB440138 mRNA. Translation: BAG71407.1.
BC084769 mRNA. Translation: AAH84769.1. Different initiation.
RefSeqiNP_001088445.1. NM_001094976.1.
UniGeneiXl.49181.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB5MFE9. 4 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi495309.
KEGGixla:495309.

Organism-specific databases

CTDi56944.
XenbaseiXB-GENE-6022244. olfml3.

Phylogenomic databases

HOVERGENiHBG108213.

Family and domain databases

InterProiIPR011043. Gal_Oxase/kelch_b-propeller.
IPR003112. Olfac-like_dom.
IPR031230. OLFML3.
[Graphical view]
PANTHERiPTHR23192:SF8. PTHR23192:SF8. 1 hit.
PfamiPF02191. OLF. 1 hit.
[Graphical view]
SMARTiSM00284. OLF. 1 hit.
[Graphical view]
SUPFAMiSSF50965. SSF50965. 1 hit.
PROSITEiPS51132. OLF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOLFL3_XENLA
AccessioniPrimary (citable) accession number: B5MFE9
Secondary accession number(s): Q5U5B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: May 11, 2016
This is version 30 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.