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Protein

Solute carrier family 52, riboflavin transporter, member 2

Gene

Slc52a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Riboflavin transporter. Riboflavin transport is Na+-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).1 Publication

GO - Molecular functioni

  • riboflavin transporter activity Source: UniProtKB

GO - Biological processi

  • riboflavin transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-196843. Vitamin B2 (riboflavin) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 52, riboflavin transporter, member 2
Alternative name(s):
Porcine endogenous retrovirus A receptor 2
Protein GPR172B
Riboflavin transporter 1
Short name:
rRFT1
Gene namesi
Name:Slc52a2
Synonyms:Gpr172a, Gpr172b, Rft1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi1560410. Slc52a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei114 – 136HelicalSequence analysisAdd BLAST23
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
Transmembranei371 – 391HelicalSequence analysisAdd BLAST21
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003997891 – 450Solute carrier family 52, riboflavin transporter, member 2Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB5MEV3.

PTM databases

PhosphoSitePlusiB5MEV3.

Expressioni

Tissue specificityi

Highly expressed in the placenta and small intestine, moderately in the kidney, colon, lung, prostate, uterus, and thymus, and weakly in all other tissues.1 Publication

Gene expression databases

BgeeiENSRNOG00000032561.
GenevisibleiB5MEV3. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046721.

Structurei

3D structure databases

ProteinModelPortaliB5MEV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the riboflavin transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
GeneTreeiENSGT00390000003774.
HOGENOMiHOG000247012.
HOVERGENiHBG051170.
InParanoidiB5MEV3.
OMAiAPLWHHV.
OrthoDBiEOG091G0BZA.
PhylomeDBiB5MEV3.
TreeFamiTF314820.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5MEV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPLGRLV LTHLLVALFG MGSWIAVNGI WVELPVVVKE LPEGWSLPSY
60 70 80 90 100
LSVLVALGNL GLLLVTLWRR LAPGKSERIP IQVVQGLSIV GTGLLAPLWS
110 120 130 140 150
NMALVAGQLH SVAFLTLAFV LALSCCASNV TFLPFLSHLP PPFLRSFFLG
160 170 180 190 200
QGLSALLPCV LALAQGVGRL ECLHVPANGT TGPPIKVSPI NFPERFSAGT
210 220 230 240 250
FFWVLTALLG TSAAAFQGLL LLLPSPPPEA TMGTGLRVET PGTEEEEEEE
260 270 280 290 300
EASPLQEPPG QVASIVSSPD PKAHRLFSSR SACLLGLLAI TNALTNGVLP
310 320 330 340 350
AVQSFSCLPY GRLAYHLAVV LGSSANPLAC FLAMAVLCRS LAGLYGLCLL
360 370 380 390 400
GMFFGTYLMT LAVLSPCPPL VGTSAGVVLV VLSWVLCAGV FSYIKVATSS
410 420 430 440 450
MLHSGGRPAL LAAGVAIQVG SLLGAIAMFP PTSVYPVFRS GEDCVDQCGP
Length:450
Mass (Da):46,956
Last modified:October 5, 2010 - v2
Checksum:i1D4ABA0DC5C5B955
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti426I → V in BAG71130 (PubMed:18632736).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB362535 mRNA. Translation: BAG71130.1.
BC133726 mRNA. Translation: AAI33727.1.
CH473950 Genomic DNA. Translation: EDM15963.1.
RefSeqiNP_001103140.1. NM_001109670.1.
XP_006241888.1. XM_006241826.3.
UniGeneiRn.29304.

Genome annotation databases

EnsembliENSRNOT00000047380; ENSRNOP00000046721; ENSRNOG00000032561.
GeneIDi362942.
KEGGirno:362942.
UCSCiRGD:1560410. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB362535 mRNA. Translation: BAG71130.1.
BC133726 mRNA. Translation: AAI33727.1.
CH473950 Genomic DNA. Translation: EDM15963.1.
RefSeqiNP_001103140.1. NM_001109670.1.
XP_006241888.1. XM_006241826.3.
UniGeneiRn.29304.

3D structure databases

ProteinModelPortaliB5MEV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046721.

PTM databases

PhosphoSitePlusiB5MEV3.

Proteomic databases

PaxDbiB5MEV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047380; ENSRNOP00000046721; ENSRNOG00000032561.
GeneIDi362942.
KEGGirno:362942.
UCSCiRGD:1560410. rat.

Organism-specific databases

CTDi79581.
RGDi1560410. Slc52a2.

Phylogenomic databases

eggNOGiKOG4255. Eukaryota.
ENOG410YE1U. LUCA.
GeneTreeiENSGT00390000003774.
HOGENOMiHOG000247012.
HOVERGENiHBG051170.
InParanoidiB5MEV3.
OMAiAPLWHHV.
OrthoDBiEOG091G0BZA.
PhylomeDBiB5MEV3.
TreeFamiTF314820.

Enzyme and pathway databases

ReactomeiR-RNO-196843. Vitamin B2 (riboflavin) metabolism.

Miscellaneous databases

PROiB5MEV3.

Gene expression databases

BgeeiENSRNOG00000032561.
GenevisibleiB5MEV3. RN.

Family and domain databases

InterProiIPR009357. Riboflavin_transptr.
[Graphical view]
PANTHERiPTHR12929. PTHR12929. 1 hit.
PfamiPF06237. DUF1011. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS52A2_RAT
AccessioniPrimary (citable) accession number: B5MEV3
Secondary accession number(s): A3KN99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 42 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.