ID   S14L6_HUMAN             Reviewed;         397 AA.
AC   B5MCN3;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   24-JAN-2024, entry version 93.
DE   RecName: Full=Putative SEC14-like protein 6;
GN   Name=SEC14L6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10591208; DOI=10.1038/990031;
RA   Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA   Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA   Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA   Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA   Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA   Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA   Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA   Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA   Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA   Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA   Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA   Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA   Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA   Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA   Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA   Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA   Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA   Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA   Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA   Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA   Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA   Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA   Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA   Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA   Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA   Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA   Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA   Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA   Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA   Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA   Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA   Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA   Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA   McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA   Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA   Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA   Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA   Wright H.;
RT   "The DNA sequence of human chromosome 22.";
RL   Nature 402:489-495(1999).
CC   -!- CAUTION: Product of a dubious gene prediction. {ECO:0000305}.
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DR   EMBL; AC004832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS54518.1; -.
DR   RefSeq; NP_001180265.2; NM_001193336.2.
DR   AlphaFoldDB; B5MCN3; -.
DR   SMR; B5MCN3; -.
DR   STRING; 9606.ENSP00000385695; -.
DR   GlyGen; B5MCN3; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; B5MCN3; -.
DR   PhosphoSitePlus; B5MCN3; -.
DR   BioMuta; SEC14L6; -.
DR   jPOST; B5MCN3; -.
DR   MassIVE; B5MCN3; -.
DR   MaxQB; B5MCN3; -.
DR   PaxDb; 9606-ENSP00000385695; -.
DR   PeptideAtlas; B5MCN3; -.
DR   ProteomicsDB; 6075; -.
DR   Antibodypedia; 77781; 4 antibodies from 4 providers.
DR   DNASU; 730005; -.
DR   Ensembl; ENST00000402034.7; ENSP00000385695.1; ENSG00000214491.9.
DR   GeneID; 730005; -.
DR   KEGG; hsa:730005; -.
DR   MANE-Select; ENST00000402034.7; ENSP00000385695.1; NM_001193336.4; NP_001180265.2.
DR   UCSC; uc021wnu.2; human.
DR   AGR; HGNC:40047; -.
DR   CTD; 730005; -.
DR   DisGeNET; 730005; -.
DR   GeneCards; SEC14L6; -.
DR   HGNC; HGNC:40047; SEC14L6.
DR   HPA; ENSG00000214491; Tissue enhanced (epididymis, parathyroid gland).
DR   neXtProt; NX_B5MCN3; -.
DR   OpenTargets; ENSG00000214491; -.
DR   VEuPathDB; HostDB:ENSG00000214491; -.
DR   eggNOG; KOG1471; Eukaryota.
DR   GeneTree; ENSGT00940000165472; -.
DR   HOGENOM; CLU_014001_2_1_1; -.
DR   InParanoid; B5MCN3; -.
DR   OMA; PDQTFME; -.
DR   OrthoDB; 6048at2759; -.
DR   PhylomeDB; B5MCN3; -.
DR   TreeFam; TF313988; -.
DR   PathwayCommons; B5MCN3; -.
DR   BioGRID-ORCS; 730005; 10 hits in 1143 CRISPR screens.
DR   ChiTaRS; SEC14L6; human.
DR   GenomeRNAi; 730005; -.
DR   Pharos; B5MCN3; Tdark.
DR   Proteomes; UP000005640; Chromosome 22.
DR   RNAct; B5MCN3; Protein.
DR   Bgee; ENSG00000214491; Expressed in metanephros cortex and 94 other cell types or tissues.
DR   ExpressionAtlas; B5MCN3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 2.60.120.680; GOLD domain; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR009038; GOLD_dom.
DR   InterPro; IPR036598; GOLD_dom_sf.
DR   PANTHER; PTHR23324; SEC14 RELATED PROTEIN; 1.
DR   PANTHER; PTHR23324:SF41; SEC14-LIKE PROTEIN 6-RELATED; 1.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   PRINTS; PR00180; CRETINALDHBP.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR   SUPFAM; SSF101576; Supernatant protein factor (SPF), C-terminal domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50866; GOLD; 1.
DR   Genevisible; B5MCN3; HS.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..397
FT                   /note="Putative SEC14-like protein 6"
FT                   /id="PRO_0000410725"
FT   DOMAIN          76..249
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   DOMAIN          252..383
FT                   /note="GOLD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00096"
SQ   SEQUENCE   397 AA;  45364 MW;  BB45CFE2EA9CBB81 CRC64;
     MSGQVGDLSP SQEKSLAQFR ENIQDVLSAL PNPDDYFLLR WLQARSFDLQ KSEDMLRKHM
     EFRKQQDLAN ILAWQPPEVV RLYNANGICG HDGEGSPVWY HIVGSLDPKG LLLSASKQEL
     LRDSFRSCEL LLRECELQSQ KLGKRVEKII AIFGLEGLGL RDLWKPGIEL LQEFFSALEA
     NYPEILKSLI VVRAPKLFAV AFNLVKSYMS EETRRKVVIL GDNWKQELTK FISPDQLPVE
     FGGTMTDPDG NPKCLTKINY GGEVPKSYYL CKQVRLQYEH TRSVGRGSSL QVENEILFPG
     CVLRWQFASD GGDIGFGVFL KTKMGERQRA REMTEVLPSQ RYNAHMVPED GILTCLQAGS
     YVLRFYNTYS LVHSKRISYT VEVLLPDQTF MEKMEKF
//