ID   B5MC47_HUMAN            Unreviewed;       873 AA.
AC   B5MC47;
DT   14-OCT-2008, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2008, sequence version 1.
DT   27-MAR-2024, entry version 82.
DE   RecName: Full=Pecanex-like protein {ECO:0000256|RuleBase:RU367089};
GN   Name=PCNX4 {ECO:0000313|Ensembl:ENSP00000385201.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000385201.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000385201.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12508121; DOI=10.1038/nature01348;
RA   Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA   Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA   Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA   Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA   Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA   Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA   Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA   Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA   Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA   Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA   Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA   Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA   Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA   Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA   Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA   Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA   Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA   Waterston R., Hood L., Weissenbach J.;
RT   "The DNA sequence and analysis of human chromosome 14.";
RL   Nature 421:601-607(2003).
RN   [2] {ECO:0000313|Ensembl:ENSP00000385201.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU367089}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU367089}.
CC   -!- SIMILARITY: Belongs to the pecanex family.
CC       {ECO:0000256|RuleBase:RU367089}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU367089}.
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DR   EMBL; AL157911; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL163853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; B5MC47; -.
DR   MassIVE; B5MC47; -.
DR   PeptideAtlas; B5MC47; -.
DR   ProteomicsDB; 5988; -.
DR   Antibodypedia; 41; 70 antibodies from 16 providers.
DR   Ensembl; ENST00000406949.5; ENSP00000385201.1; ENSG00000126773.13.
DR   UCSC; uc001xeq.3; human.
DR   HGNC; HGNC:20349; PCNX4.
DR   VEuPathDB; HostDB:ENSG00000126773; -.
DR   GeneTree; ENSGT00940000156899; -.
DR   ChiTaRS; PCNX4; human.
DR   Proteomes; UP000005640; Chromosome 14.
DR   Bgee; ENSG00000126773; Expressed in ventricular zone and 193 other cell types or tissues.
DR   ExpressionAtlas; B5MC47; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039797; Pecanex.
DR   PANTHER; PTHR12372; PECANEX; 1.
DR   PANTHER; PTHR12372:SF6; PECANEX-LIKE PROTEIN 4; 1.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|RuleBase:RU367089};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:B5MC47,
KW   ECO:0007829|ProteomicsDB:B5MC47};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU367089};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU367089}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..873
FT                   /note="Pecanex-like protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002836708"
FT   TRANSMEM        12..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        80..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        122..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        155..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        300..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        331..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
FT   TRANSMEM        402..424
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU367089"
SQ   SEQUENCE   873 AA;  98944 MW;  9F7671AC6E136047 CRC64;
     MPALEHMNQI LHILFVFLPF LWALGTLPPP DALLLWAMEQ VLEFGLGGSS MSTHLRLLVM
     FIMSAGTAIA SYFIPSTVGV VLFMTGFGFL LSLNLSDMGH KIGTKSKDLP SGPEKHFSWK
     ECLFYIIILV LALLETSLLH HFAGFSQISK SNSQAIVGYG LMILLIILWI LREIQSVYII
     GIFRNPFYPK DVQTVTVFFE KQTRLMKIGI VRRILLTLVS PFAMIAFLSL DSSLQGLHSV
     SVCIGFTRAF RMVWQNTENA LLETVIVSTV HLISSTDIWW NRSLDTGLRL LLVGIIRDRL
     IQFISKLQFA VTVLLTSWTE KKQRRKTTAT LCILNIVFSP FVLVIIVFST LLSSPLLPLF
     TLPVFLVGFP RPIQSWPGAA GTTACVCADT VYYYQMVPRL TAVLQTAMAA GSLGLLLPGS
     HYLGRFQDRL MWIMILECGY TYCSINIKGL ELQETSCHTA EARRVDEVFE DAFEQEYTRV
     CSLNEHFGNV LTPCTVLPVK LYSDARNVLS GIIDSHENLK EFKGDLIKVL VWILVQYCSK
     RPGMKENVHN TENKGKAPLM LPALNTLPPP KSPEDIDSLN SETFNDWSDD NIFDDEPTIK
     KVIEEKHQLK DLPGTNLFIP GSVESQRVGD HSTGTVPEND LYKAVLLGYP AVDKGKQEDM
     PYIPLMEFSC SHSHLVCLPA EWRTSCMPSS KMKEMSSLFP EDWYQFVLRQ LECYHSEEKA
     SNVLEEIAKD KVLKDFYVHT VMTCYFSLFG IDNMAPSPGH ILRVYGGVLP WSVALDWLTE
     KPELFQLALK AFRYTLKLMI DKASLGPIED FRELIKYLEE YERDWYIGLV SDEKWKEAIL
     QEKPYLFSLG YDSNMPGPAL EISRVNRNLW SQI
//