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B5MC21

- B5MC21_HUMAN

UniProt

B5MC21 - B5MC21_HUMAN

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Protein
Submitted name: Interleukin-6
Gene
IL6
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Biological processi

  1. T cell activation Source: Ensembl
  2. aging Source: Ensembl
  3. bone remodeling Source: Ensembl
  4. branching involved in salivary gland morphogenesis Source: Ensembl
  5. cell growth Source: Ensembl
  6. cell redox homeostasis Source: Ensembl
  7. defense response to protozoan Source: Ensembl
  8. endocrine pancreas development Source: Ensembl
  9. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
  10. glucagon secretion Source: Ensembl
  11. immune response Source: InterPro
  12. interleukin-6-mediated signaling pathway Source: Ensembl
  13. muscle cell cellular homeostasis Source: Ensembl
  14. negative regulation of cell proliferation Source: Ensembl
  15. negative regulation of chemokine biosynthetic process Source: Ensembl
  16. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  17. negative regulation of cytokine secretion Source: Ensembl
  18. negative regulation of gluconeogenesis Source: Ensembl
  19. negative regulation of hormone secretion Source: Ensembl
  20. negative regulation of muscle organ development Source: Ensembl
  21. negative regulation of neuron death Source: Ensembl
  22. negative regulation of protein kinase activity Source: Ensembl
  23. neutrophil apoptotic process Source: Ensembl
  24. positive regulation of DNA replication Source: Ensembl
  25. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  26. positive regulation of T-helper 2 cell differentiation Source: Ensembl
  27. positive regulation of epithelial cell proliferation Source: Ensembl
  28. positive regulation of neuron differentiation Source: Ensembl
  29. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  30. positive regulation of protein import into nucleus, translocation Source: Ensembl
  31. positive regulation of protein kinase B signaling Source: Ensembl
  32. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  33. positive regulation of transmission of nerve impulse Source: Ensembl
  34. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  35. regulation of cell shape Source: Ensembl
  36. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  37. response to amino acid Source: Ensembl
  38. response to antibiotic Source: Ensembl
  39. response to caffeine Source: Ensembl
  40. response to calcium ion Source: Ensembl
  41. response to cold Source: Ensembl
  42. response to drug Source: Ensembl
  43. response to electrical stimulus Source: Ensembl
  44. response to heat Source: Ensembl
  45. response to insulin Source: Ensembl
  46. response to lipopolysaccharide Source: Ensembl
  47. response to mechanical stimulus Source: Ensembl
  48. response to nutrient levels Source: Ensembl
  49. response to wounding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-6Imported
Gene namesi
Name:IL6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:6018. IL6.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular space Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ArrayExpressiB5MC21.
BgeeiB5MC21.

Structurei

3D structure databases

ProteinModelPortaliB5MC21.
SMRiB5MC21. Positions 1-136.

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000236330.
HOVERGENiHBG000471.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR11457. PTHR11457. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
PRINTSiPR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTiSM00126. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5MC21-1 [UniParc]FASTAAdd to Basket

« Hide

MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEETCLVKII TGLLEFEVYL    50
EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PDPTTNASLL 100
TKLQAQNQWL QDMTTHLILR SFKEFLQSSL RALRQM 136
Length:136
Mass (Da):15,596
Last modified:October 14, 2008 - v1
Checksum:iDE6D1905F32FF15E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073072 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000407492; ENSP00000385043; ENSG00000136244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC073072 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B5MC21.
SMRi B5MC21. Positions 1-136.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000407492 ; ENSP00000385043 ; ENSG00000136244 .

Organism-specific databases

HGNCi HGNC:6018. IL6.
GenAtlasi Search...

Phylogenomic databases

HOGENOMi HOG000236330.
HOVERGENi HBG000471.

Miscellaneous databases

ChiTaRSi IL6. human.
GenomeRNAii 3569.
NextBioi 35478051.

Gene expression databases

ArrayExpressi B5MC21.
Bgeei B5MC21.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR003574. IL-6.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view ]
PANTHERi PTHR11457. PTHR11457. 1 hit.
Pfami PF00489. IL6. 1 hit.
[Graphical view ]
PRINTSi PR00433. IL6GCSFMGF.
PR00434. INTERLEUKIN6.
SMARTi SM00126. IL6. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB5MC21_HUMAN
AccessioniPrimary (citable) accession number: B5MC21
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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