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Protein
Submitted name:

Echinoderm microtubule-associated protein-like 4

Gene

EML4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiB5MBZ0

Names & Taxonomyi

Protein namesi
Submitted name:
Echinoderm microtubule-associated protein-like 4Imported
Gene namesi
Name:EML4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143924.18
HGNCiHGNC:1316 EML4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143924

PTM / Processingi

Proteomic databases

EPDiB5MBZ0
MaxQBiB5MBZ0
PeptideAtlasiB5MBZ0
PRIDEiB5MBZ0

Expressioni

Gene expression databases

BgeeiENSG00000143924
ExpressionAtlasiB5MBZ0 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB5MBZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini516 – 557WD_REPEATS_REGIONInterPro annotationAdd BLAST42
Repeati516 – 548WDPROSITE-ProRule annotationAdd BLAST33
Domaini599 – 769WD_REPEATS_REGIONInterPro annotationAdd BLAST171
Repeati599 – 631WDPROSITE-ProRule annotationAdd BLAST33
Repeati728 – 769WDPROSITE-ProRule annotationAdd BLAST42
Domaini841 – 883WD_REPEATS_REGIONInterPro annotationAdd BLAST43
Repeati841 – 875WDPROSITE-ProRule annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili17 – 51Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISA0 Eukaryota
COG2319 LUCA
GeneTreeiENSGT00550000074369
HOGENOMiHOG000294061
HOVERGENiHBG051470
OMAiGHCADFH
OrthoDBiEOG091G04Z4
PhylomeDBiB5MBZ0

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03451 HELP, 1 hit
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 9 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 3 hits

Sequencei

Sequence statusi: Complete.

B5MBZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR
60 70 80 90 100
RLAISEDHVA SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS
110 120 130 140 150
IAGKETLSSA AKSGTEKKKE KPQGQREKKE ESHSNDQSPQ IRASPSPQPS
160 170 180 190 200
SQPLQIHRQT PESKNATPTK SIKRPSPAEK SHNSWENSDD SRNKLSKIPS
210 220 230 240 250
TPKLIPKVTK TADKHKDVII NQAKMSTREK NSQEGEYIKM FMRGRPITMF
260 270 280 290 300
IPSDVDNYDD IRTELPPEKL KLEWAYGYRG KDCRANVYLL PTGKIVYFIA
310 320 330 340 350
SVVVLFNYEE RTQRHYLGHT DCVKCLAIHP DKIRIATGQI AGVDKDGRPL
360 370 380 390 400
QPHVRVWDSV TLSTLQIIGL GTFERGVGCL DFSKADSGVH LCIIDDSNEH
410 420 430 440 450
MLTVWDWQKK AKGAEIKTTN EVVLAVEFHP TDANTIITCG KSHIFFWTWS
460 470 480 490 500
GNSLTRKQGI FGKYEKPKFV QCLAFLGNGD VLTGDSGGVM LIWSKTTVEP
510 520 530 540 550
TPGKGPKGVY QISKQIKAHD GSVFTLCQMR NGMLLTGGGK DRKIILWDHD
560 570 580 590 600
LNPEREIEVP DQYGTIRAVA EGKADQFLVG TSRNFILRGT FNDGFQIEVQ
610 620 630 640 650
GHTDELWGLA THPFKDLLLT CAQDRQVCLW NSMEHRLEWT RLVDEPGHCA
660 670 680 690 700
DFHPSGTVVA IGTHSGRWFV LDAETRDLVS IHTDGNEQLS VMRYSIDGTF
710 720 730 740 750
LAVGSHDNFI YLYVVSENGR KYSRYGRCTG HSSYITHLDW SPDNKYIMSN
760 770 780 790 800
SGDYEILYWD IPNGCKLIRN RSDCKDIDWT TYTCVLGFQV FGVWPEGSDG
810 820 830 840 850
TDINALVRSH NRKVIAVADD FCKVHLFQYP CSKAKAPSHK YSAHSSHVTN
860 870 880 890 900
VSFTHNDSHL ISTGGKDMSI IQWKLVEKLS LPQNETVADT TLTKAPVSST
910 920 930 940 950
ESVIQSNTPT PPPSQPLNET AEEESRISSS PTLLENSLEQ TVEPSEDHSE
960 970 980 990
EESEEGSGDL GEPLYEEPCN EISKEQAKAT LLEDQQDPSP SS
Length:992
Mass (Da):110,178
Last modified:April 5, 2011 - v3
Checksum:i0F3A05B3B4663582
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006038 Genomic DNA No translation available.
AC083949 Genomic DNA No translation available.
AC096668 Genomic DNA No translation available.
RefSeqiXP_005264324.1, XM_005264267.1
UniGeneiHs.713173

Genome annotation databases

EnsembliENST00000401738; ENSP00000384939; ENSG00000143924
GeneIDi27436
UCSCiuc061iox.1 human

Similar proteinsi

Entry informationi

Entry nameiB5MBZ0_HUMAN
AccessioniPrimary (citable) accession number: B5MBZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: April 5, 2011
Last modified: June 20, 2018
This is version 85 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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