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Protein
Submitted name:

Echinoderm microtubule-associated protein-like 4

Gene

EML4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiB5MBZ0.

Names & Taxonomyi

Protein namesi
Submitted name:
Echinoderm microtubule-associated protein-like 4Imported
Gene namesi
Name:EML4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1316. EML4.

PTM / Processingi

Proteomic databases

MaxQBiB5MBZ0.
PaxDbiB5MBZ0.
PeptideAtlasiB5MBZ0.
PRIDEiB5MBZ0.

Expressioni

Gene expression databases

BgeeiENSG00000143924.
ExpressionAtlasiB5MBZ0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320663.

Structurei

3D structure databases

ProteinModelPortaliB5MBZ0.
SMRiB5MBZ0. Positions 16-44, 232-949.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini516 – 55742WD_REPEATS_REGIONInterPro annotationAdd
BLAST
Domaini599 – 769171WD_REPEATS_REGIONInterPro annotationAdd
BLAST
Domaini841 – 88343WD_REPEATS_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili17 – 5135Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISA0. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000294061.
HOVERGENiHBG051470.
OMAiPKGVYQI.
OrthoDBiEOG091G04Z4.
PhylomeDBiB5MBZ0.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5MBZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGFAGSLDD SISAASTSDV QDRLSALESR VQQQEDEITV LKAALADVLR
60 70 80 90 100
RLAISEDHVA SVKKSVSSKG QPSPRAVIPM SCITNGSGAN RKPSHTSAVS
110 120 130 140 150
IAGKETLSSA AKSGTEKKKE KPQGQREKKE ESHSNDQSPQ IRASPSPQPS
160 170 180 190 200
SQPLQIHRQT PESKNATPTK SIKRPSPAEK SHNSWENSDD SRNKLSKIPS
210 220 230 240 250
TPKLIPKVTK TADKHKDVII NQAKMSTREK NSQEGEYIKM FMRGRPITMF
260 270 280 290 300
IPSDVDNYDD IRTELPPEKL KLEWAYGYRG KDCRANVYLL PTGKIVYFIA
310 320 330 340 350
SVVVLFNYEE RTQRHYLGHT DCVKCLAIHP DKIRIATGQI AGVDKDGRPL
360 370 380 390 400
QPHVRVWDSV TLSTLQIIGL GTFERGVGCL DFSKADSGVH LCIIDDSNEH
410 420 430 440 450
MLTVWDWQKK AKGAEIKTTN EVVLAVEFHP TDANTIITCG KSHIFFWTWS
460 470 480 490 500
GNSLTRKQGI FGKYEKPKFV QCLAFLGNGD VLTGDSGGVM LIWSKTTVEP
510 520 530 540 550
TPGKGPKGVY QISKQIKAHD GSVFTLCQMR NGMLLTGGGK DRKIILWDHD
560 570 580 590 600
LNPEREIEVP DQYGTIRAVA EGKADQFLVG TSRNFILRGT FNDGFQIEVQ
610 620 630 640 650
GHTDELWGLA THPFKDLLLT CAQDRQVCLW NSMEHRLEWT RLVDEPGHCA
660 670 680 690 700
DFHPSGTVVA IGTHSGRWFV LDAETRDLVS IHTDGNEQLS VMRYSIDGTF
710 720 730 740 750
LAVGSHDNFI YLYVVSENGR KYSRYGRCTG HSSYITHLDW SPDNKYIMSN
760 770 780 790 800
SGDYEILYWD IPNGCKLIRN RSDCKDIDWT TYTCVLGFQV FGVWPEGSDG
810 820 830 840 850
TDINALVRSH NRKVIAVADD FCKVHLFQYP CSKAKAPSHK YSAHSSHVTN
860 870 880 890 900
VSFTHNDSHL ISTGGKDMSI IQWKLVEKLS LPQNETVADT TLTKAPVSST
910 920 930 940 950
ESVIQSNTPT PPPSQPLNET AEEESRISSS PTLLENSLEQ TVEPSEDHSE
960 970 980 990
EESEEGSGDL GEPLYEEPCN EISKEQAKAT LLEDQQDPSP SS
Length:992
Mass (Da):110,178
Last modified:April 5, 2011 - v3
Checksum:i0F3A05B3B4663582
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006038 Genomic DNA. No translation available.
AC083949 Genomic DNA. No translation available.
AC096668 Genomic DNA. No translation available.
RefSeqiXP_005264324.1. XM_005264267.1.
UniGeneiHs.713173.

Genome annotation databases

EnsembliENST00000401738; ENSP00000384939; ENSG00000143924.
GeneIDi27436.
UCSCiuc061iox.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006038 Genomic DNA. No translation available.
AC083949 Genomic DNA. No translation available.
AC096668 Genomic DNA. No translation available.
RefSeqiXP_005264324.1. XM_005264267.1.
UniGeneiHs.713173.

3D structure databases

ProteinModelPortaliB5MBZ0.
SMRiB5MBZ0. Positions 16-44, 232-949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320663.

Proteomic databases

MaxQBiB5MBZ0.
PaxDbiB5MBZ0.
PeptideAtlasiB5MBZ0.
PRIDEiB5MBZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000401738; ENSP00000384939; ENSG00000143924.
GeneIDi27436.
UCSCiuc061iox.1. human.

Organism-specific databases

CTDi27436.
HGNCiHGNC:1316. EML4.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISA0. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000294061.
HOVERGENiHBG051470.
OMAiPKGVYQI.
OrthoDBiEOG091G04Z4.
PhylomeDBiB5MBZ0.

Enzyme and pathway databases

SignaLinkiB5MBZ0.

Miscellaneous databases

ChiTaRSiEML4. human.
GenomeRNAii27436.

Gene expression databases

BgeeiENSG00000143924.
ExpressionAtlasiB5MBZ0. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR005108. HELP.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 9 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF50998. SSF50998. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 4 hits.
PS50294. WD_REPEATS_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB5MBZ0_HUMAN
AccessioniPrimary (citable) accession number: B5MBZ0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 66 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.