B5M9L0 (B5M9L0_STRLS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lasalocid modular polyketide synthase EMBL CAQ64688.1

Gene names

Name:

lasAIII EMBL CAQ64688.1

Organism

Streptomyces lasaliensis EMBL CAQ64688.1

Taxonomic identifier

324833 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	1108 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Molecular_function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5M9L0 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: D253F408BD4713B8	FASTA	1,108	118,668
	10 20 30 40 50 60 MPNTEEKLLD YLKRVTADLK QTQRRLREAE AADTEPIAIV GMGCRYPGDV RSADDLWGLL 70 80 90 100 110 120 AEGGDAISKF PDDRGWNTEE LYDPDPDRPG RNYVREGGFL HDATEFDADF FGISPREALA 130 140 150 160 170 180 MDPQQRIMLE VAWETFEHAG LDPQSFGGSD TGVFVGISNV DYTWGHARVP EAVEGYFGTG 190 200 210 220 230 240 NFASVLSGRL AYTFGLEGPA LTVDTACSSS LVALHLATQA LRRGECGAAL VGGVTVMSNP 250 260 270 280 290 300 SGFVEFSRQR GLAPDGRCKA FAAAADGFGP SEGAGVLLVE RLSDARRNGH RVLAVVRGSA 310 320 330 340 350 360 VNQDGASNGL SAPNGPSQQR VIRQALRNAR LSPEQVDAVE AHGTGTTLGD PIEAQALLAT 370 380 390 400 410 420 YGQGRPEDRP LWLGSVKSNI GHTSAAAGVA GVIKMVMAMR HGVLPRSLHI DEPTPQVDWS 430 440 450 460 470 480 SGAVTLLTEP VDWPDSDRPR RAGVSAFGIS GTNAHVILEQ APTQDPQQPA PPVPAAPWLL 490 500 510 520 530 540 SAKTPAALRA QARRLHTHLT RHPHPDPTDI AHALATTRTP HEHRAALVTD DHGTLLHGLL 550 560 570 580 590 600 ALGEESVAPY VVEPGRAVAG KTVFVFPGQG SQWTGMGREL LDTSEQFAAY IAECETALND 610 620 630 640 650 660 FVDWSLTDVL RGTEGAPGYD RVDVVQPALF AVMVSLARLW QHHGIHPDAV IGHSQGEIAA 670 680 690 700 710 720 AHIAGALTLN DAARIVALRS QALLPLAGLG GMTSLALPHH QAHELIQPWG QDLSIASVNG 730 740 750 760 770 780 PHSTVVSGTT HALDELHTTC NTQGVRARRI PVDYASHSAQ VESIRDTVLQ AATGINPQPT 790 800 810 820 830 840 TIPLYSTVTG QPIDGTQLDA DYWYTNLRHT VRFEETTRAL LGSGHRHFIE TTAHPVLALA 850 860 870 880 890 900 LEETIEATGS DARVTGTLRR DHGDLTQLHT ALATAWTHGV DVDWTAVVPG AGRRRVDLPT 910 920 930 940 950 960 YAFQRRRYWL EPGVVPVSDT VPVAVVDEAE SGEAATALAR ALADASEAGR EALLIDLVQS 970 980 990 1000 1010 1020 RVAAVLGHEE PESVDTERAF KDLGFDSLTA TQLRNRLNAA TGLRLPATLV FSHPTPKALA 1030 1040 1050 1060 1070 1080 QYLAGVIRPD EEAAARPPAL RDIDLLEDSL WAQSFDAATR DLVARRLDAL LRRWSAGGTT 1090 1100 EEGVDEAALD TASDDELFQI LDEQLGNA

References

[1]	"The biosynthetic gene cluster responsible for Lasalocid production from Streptomyces lasaliensis." Smith L., Samborskyy M., Fan Q., Spencer J.B., Leadlay P.F. Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: NRRL 3382R EMBL CAQ64688.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FM173265 Genomic DNA. Translation: CAQ64688.1.
3D structure databases
ProteinModelPortal	B5M9L0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.1200.10. 1 hit. 3.40.366.10. 2 hits. 3.40.47.10. 2 hits.
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020806. PKS_PP-bd. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF101173. Polyketide_synth_docking. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5M9L0_STRLS

Accession

Primary (citable) accession number: B5M9L0

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	March 6, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)