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B5IEE5

- PSB_ACIB4

UniProt

B5IEE5 - PSB_ACIB4

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Protein

Proteasome subunit beta

Gene
psmB, Aboo_0123, ABOONEI_2767, ABOONEI_326
Organism
Aciduliprofundum boonei (strain DSM 19572 / T469)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Nucleophile By similarity

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. proteasomal protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciABOO439481:GJNL-126-MONOMER.

Protein family/group databases

MEROPSiT01.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta (EC:3.4.25.1)
Alternative name(s):
20S proteasome beta subunit
Proteasome core protein PsmB
Gene namesi
Name:psmB
Ordered Locus Names:Aboo_0123
ORF Names:ABOONEI_2767, ABOONEI_326
OrganismiAciduliprofundum boonei (strain DSM 19572 / T469)
Taxonomic identifieri439481 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaAciduliprofundum
ProteomesiUP000001400: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, beta-subunit complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 77Removed in mature form; by autocatalysis By similarityPRO_0000397272
Chaini8 – 210203Proteasome subunit betaUniRule annotationPRO_0000397273Add
BLAST

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN By similarity.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.

Phylogenomic databases

HOGENOMiHOG000091083.
KOiK03433.
OMAiGYYIAHR.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_02113_A. Proteasome_B_A.
InterProiIPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
PRINTSiPR00141. PROTEASOME.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03634. arc_protsome_B. 1 hit.
PROSITEiPS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B5IEE5-1 [UniParc]FASTAAdd to Basket

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MENAKTGTTT VGIVTKDGVV MGTEHRASME TFIAHKTAQK LYKLDYNIGM    50
TTAGLVGDLQ VLVRYMRAEI NLYRIRRKMY MPVGAAATLL SNILNERKFF 100
PYYVGLLVGG FDSKGYHVFA IDAAGGAIED KYASVGSGSL FVYGVLEDRW 150
KDDLSLDEGI NLVIRGINAA MRRDAASGDG ISVATITKDE GFVELSQEEV 200
EKRMKKLKLK 210
Length:210
Mass (Da):23,132
Last modified:October 14, 2008 - v1
Checksum:i582EFEE945B50FE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001941 Genomic DNA. Translation: ADD07935.1.
DS990524 Genomic DNA. Translation: EDY35255.1.
DS990523 Genomic DNA. Translation: EDY35319.1.
RefSeqiYP_003482497.1. NC_013926.1.

Genome annotation databases

EnsemblBacteriaiADD07935; ADD07935; Aboo_0123.
EDY35255; EDY35255; ABOONEI_326.
EDY35319; EDY35319; ABOONEI_2767.
GeneIDi8827059.
KEGGiabi:Aboo_0123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001941 Genomic DNA. Translation: ADD07935.1 .
DS990524 Genomic DNA. Translation: EDY35255.1 .
DS990523 Genomic DNA. Translation: EDY35319.1 .
RefSeqi YP_003482497.1. NC_013926.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi T01.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD07935 ; ADD07935 ; Aboo_0123 .
EDY35255 ; EDY35255 ; ABOONEI_326 .
EDY35319 ; EDY35319 ; ABOONEI_2767 .
GeneIDi 8827059.
KEGGi abi:Aboo_0123.

Phylogenomic databases

HOGENOMi HOG000091083.
KOi K03433.
OMAi GYYIAHR.

Enzyme and pathway databases

BioCyci ABOO439481:GJNL-126-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_02113_A. Proteasome_B_A.
InterProi IPR029055. Ntn_hydrolases_N.
IPR019983. Pept_T1A_Psome_bsu_arc.
IPR000243. Pept_T1A_subB.
IPR001353. Proteasome_sua/b.
IPR023333. Proteasome_suB-type.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
PRINTSi PR00141. PROTEASOME.
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03634. arc_protsome_B. 1 hit.
PROSITEi PS51476. PROTEASOME_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Aciduliprofundum boonei T469."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19572 / T469.

Entry informationi

Entry nameiPSB_ACIB4
AccessioniPrimary (citable) accession number: B5IEE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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