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B5IAJ6

- HPRT_ACIB4

UniProt

B5IAJ6 - HPRT_ACIB4

Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Aciduliprofundum boonei (strain DSM 19572 / T469)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciABOO439481:GJNL-862-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
    Short name:
    HGPRTaseUniRule annotation
    Gene namesi
    Name:hptUniRule annotation
    Ordered Locus Names:Aboo_0837
    ORF Names:ABOONEI_1891, ABOONEI_908
    OrganismiAciduliprofundum boonei (strain DSM 19572 / T469)
    Taxonomic identifieri439481 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaAciduliprofundum
    ProteomesiUP000001400: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415446Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliB5IAJ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000228520.
    KOiK00759.
    OMAiIATDIPY.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01467. Hypx_phosphoribosyltr.
    InterProiIPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5IAJ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLKESLKN APVIMKGNYP YFIHPLTDGI PEIDPAVLKD AVNEIIKVID    50
    IDNFDKIVAV EAMGLPIGVA LSMELTKPMT VIRKRPYGLS GEVMVEQQTG 100
    YSKGKLYINS ISSQDTLLLV DDVLSTGGTI TAVVDGIKKI GAKISDIVVV 150
    VNKNRNIKEV EQKIGFKIKT IVNIEIVDGK VKVLD 185
    Length:185
    Mass (Da):20,218
    Last modified:October 14, 2008 - v1
    Checksum:i4678F07DDC78B1DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001941 Genomic DNA. Translation: ADD08646.1.
    DS990530 Genomic DNA. Translation: EDY34662.1.
    DS990515 Genomic DNA. Translation: EDY36970.1.
    RefSeqiWP_008082436.1. NZ_DS990530.1.
    YP_003483208.1. NC_013926.1.

    Genome annotation databases

    EnsemblBacteriaiADD08646; ADD08646; Aboo_0837.
    EDY34662; EDY34662; ABOONEI_908.
    EDY36970; EDY36970; ABOONEI_1891.
    GeneIDi8827787.
    KEGGiabi:Aboo_0837.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001941 Genomic DNA. Translation: ADD08646.1 .
    DS990530 Genomic DNA. Translation: EDY34662.1 .
    DS990515 Genomic DNA. Translation: EDY36970.1 .
    RefSeqi WP_008082436.1. NZ_DS990530.1.
    YP_003483208.1. NC_013926.1.

    3D structure databases

    ProteinModelPortali B5IAJ6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD08646 ; ADD08646 ; Aboo_0837 .
    EDY34662 ; EDY34662 ; ABOONEI_908 .
    EDY36970 ; EDY36970 ; ABOONEI_1891 .
    GeneIDi 8827787.
    KEGGi abi:Aboo_0837.

    Phylogenomic databases

    HOGENOMi HOG000228520.
    KOi K00759.
    OMAi IATDIPY.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci ABOO439481:GJNL-862-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01467. Hypx_phosphoribosyltr.
    InterProi IPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Aciduliprofundum boonei T469."
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19572 / T469.

    Entry informationi

    Entry nameiHPRT_ACIB4
    AccessioniPrimary (citable) accession number: B5IAJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3