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B5IAJ6 (HPRT_ACIB4) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hypoxanthine/guanine phosphoribosyltransferase

Short name=HGPRTase
EC=2.4.2.8
Gene names
Name:hpt
Ordered Locus Names:Aboo_0837
ORF Names:ABOONEI_1891, ABOONEI_908
OrganismAciduliprofundum boonei (strain DSM 19572 / T469) [Complete proteome] [HAMAP]
Taxonomic identifier439481 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaAciduliprofundum

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_01467

Catalytic activity

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01467

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1. HAMAP-Rule MF_01467

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01467

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01467.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processIMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionguanine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

hypoxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185Hypoxanthine/guanine phosphoribosyltransferase HAMAP-Rule MF_01467
PRO_0000415446

Sequences

Sequence LengthMass (Da)Tools
B5IAJ6 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 4678F07DDC78B1DD

FASTA18520,218
        10         20         30         40         50         60 
MKLLKESLKN APVIMKGNYP YFIHPLTDGI PEIDPAVLKD AVNEIIKVID IDNFDKIVAV 

        70         80         90        100        110        120 
EAMGLPIGVA LSMELTKPMT VIRKRPYGLS GEVMVEQQTG YSKGKLYINS ISSQDTLLLV 

       130        140        150        160        170        180 
DDVLSTGGTI TAVVDGIKKI GAKISDIVVV VNKNRNIKEV EQKIGFKIKT IVNIEIVDGK 


VKVLD 

« Hide

References

[1]"Complete sequence of Aciduliprofundum boonei T469."
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.
Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 19572 / T469.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001941 Genomic DNA. Translation: ADD08646.1.
DS990530 Genomic DNA. Translation: EDY34662.1.
DS990515 Genomic DNA. Translation: EDY36970.1.
RefSeqYP_003483208.1. NC_013926.1.

3D structure databases

ProteinModelPortalB5IAJ6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADD08646; ADD08646; Aboo_0837.
EDY34662; EDY34662; ABOONEI_908.
EDY36970; EDY36970; ABOONEI_1891.
GeneID8827787.
KEGGabi:Aboo_0837.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000228520.
KOK00759.
OMAIATDIPY.

Enzyme and pathway databases

BioCycABOO439481:GJNL-862-MONOMER.
UniPathwayUPA00591; UER00648.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01467. Hypx_phosphoribosyltr.
InterProIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
PROSITEPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHPRT_ACIB4
AccessionPrimary (citable) accession number: B5IAJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 14, 2008
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways