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B5IAJ6

- HPRT_ACIB4

UniProt

B5IAJ6 - HPRT_ACIB4

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Protein
Hypoxanthine/guanine phosphoribosyltransferase
Gene
hpt, Aboo_0837, ABOONEI_1891, ABOONEI_908
Organism
Aciduliprofundum boonei (strain DSM 19572 / T469)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis By similarity.UniRule annotation

Catalytic activityi

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
  2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. IMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciABOO439481:GJNL-862-MONOMER.
UniPathwayiUPA00591; UER00648.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxanthine/guanine phosphoribosyltransferase (EC:2.4.2.8)
Short name:
HGPRTase
Gene namesi
Name:hpt
Ordered Locus Names:Aboo_0837
ORF Names:ABOONEI_1891, ABOONEI_908
OrganismiAciduliprofundum boonei (strain DSM 19572 / T469)
Taxonomic identifieri439481 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaAciduliprofundum
ProteomesiUP000001400: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation
PRO_0000415446Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5IAJ6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000228520.
KOiK00759.
OMAiIATDIPY.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01467. Hypx_phosphoribosyltr.
InterProiIPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B5IAJ6-1 [UniParc]FASTAAdd to Basket

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MKLLKESLKN APVIMKGNYP YFIHPLTDGI PEIDPAVLKD AVNEIIKVID    50
IDNFDKIVAV EAMGLPIGVA LSMELTKPMT VIRKRPYGLS GEVMVEQQTG 100
YSKGKLYINS ISSQDTLLLV DDVLSTGGTI TAVVDGIKKI GAKISDIVVV 150
VNKNRNIKEV EQKIGFKIKT IVNIEIVDGK VKVLD 185
Length:185
Mass (Da):20,218
Last modified:October 14, 2008 - v1
Checksum:i4678F07DDC78B1DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001941 Genomic DNA. Translation: ADD08646.1.
DS990530 Genomic DNA. Translation: EDY34662.1.
DS990515 Genomic DNA. Translation: EDY36970.1.
RefSeqiWP_008082436.1. NZ_DS990530.1.
YP_003483208.1. NC_013926.1.

Genome annotation databases

EnsemblBacteriaiADD08646; ADD08646; Aboo_0837.
EDY34662; EDY34662; ABOONEI_908.
EDY36970; EDY36970; ABOONEI_1891.
GeneIDi8827787.
KEGGiabi:Aboo_0837.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001941 Genomic DNA. Translation: ADD08646.1 .
DS990530 Genomic DNA. Translation: EDY34662.1 .
DS990515 Genomic DNA. Translation: EDY36970.1 .
RefSeqi WP_008082436.1. NZ_DS990530.1.
YP_003483208.1. NC_013926.1.

3D structure databases

ProteinModelPortali B5IAJ6.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADD08646 ; ADD08646 ; Aboo_0837 .
EDY34662 ; EDY34662 ; ABOONEI_908 .
EDY36970 ; EDY36970 ; ABOONEI_1891 .
GeneIDi 8827787.
KEGGi abi:Aboo_0837.

Phylogenomic databases

HOGENOMi HOG000228520.
KOi K00759.
OMAi IATDIPY.

Enzyme and pathway databases

UniPathwayi UPA00591 ; UER00648 .
BioCyci ABOO439481:GJNL-862-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01467. Hypx_phosphoribosyltr.
InterProi IPR026597. HGPRTase-like.
IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Aciduliprofundum boonei T469."
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 19572 / T469.

Entry informationi

Entry nameiHPRT_ACIB4
AccessioniPrimary (citable) accession number: B5IAJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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