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B5I9H4

- RIBL_ACIB4

UniProt

B5I9H4 - RIBL_ACIB4

Protein

FAD synthase

Gene

ribL

Organism
Aciduliprofundum boonei (strain DSM 19572 / T469)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201ATP; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 102ATPUniRule annotation
    Nucleotide bindingi14 – 174ATPUniRule annotation
    Nucleotide bindingi91 – 944ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-HAMAP
    2. FMN metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABOO439481:GJNL-767-MONOMER.
    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
    Alternative name(s):
    FMN adenylyltransferaseUniRule annotation
    Flavin adenine dinucleotide synthaseUniRule annotation
    Gene namesi
    Name:ribLUniRule annotation
    Ordered Locus Names:Aboo_0747
    ORF Names:ABOONEI_1934, ABOONEI_2228
    OrganismiAciduliprofundum boonei (strain DSM 19572 / T469)
    Taxonomic identifieri439481 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaAciduliprofundum
    ProteomesiUP000001400: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149FAD synthasePRO_0000406231Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal FAD synthase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000284153.
    KOiK14656.
    OMAiIVLGHDQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_02115. FAD_synth_arch.
    InterProiIPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5I9H4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRVMATGVF DILHPGHVLF LREARKLGDE LVVVVARDST VERLKHKPIM    50
    NEDIRRFMVE SLKPVDRAVL GHKDDMYKTV EDVRPDIIVL GYDQKFDEKE 100
    IEEECRKRGI KVKVVRLKKY GDSDLNGTRK IIFKIVDRVD DLYAKDRNS 149
    Length:149
    Mass (Da):17,380
    Last modified:October 14, 2008 - v1
    Checksum:iF820A8DD1EC44056
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251R → K in EDY36241. (PubMed:18445019)Curated
    Sequence conflicti53 – 531D → E in EDY36241. (PubMed:18445019)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS990515 Genomic DNA. Translation: EDY37013.1.
    DS990517 Genomic DNA. Translation: EDY36241.1.
    CP001941 Genomic DNA. Translation: ADD08556.1.
    RefSeqiYP_003483118.1. NC_013926.1.

    Genome annotation databases

    EnsemblBacteriaiADD08556; ADD08556; Aboo_0747.
    EDY36241; EDY36241; ABOONEI_2228.
    EDY37013; EDY37013; ABOONEI_1934.
    GeneIDi8827694.
    KEGGiabi:Aboo_0747.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS990515 Genomic DNA. Translation: EDY37013.1 .
    DS990517 Genomic DNA. Translation: EDY36241.1 .
    CP001941 Genomic DNA. Translation: ADD08556.1 .
    RefSeqi YP_003483118.1. NC_013926.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADD08556 ; ADD08556 ; Aboo_0747 .
    EDY36241 ; EDY36241 ; ABOONEI_2228 .
    EDY37013 ; EDY37013 ; ABOONEI_1934 .
    GeneIDi 8827694.
    KEGGi abi:Aboo_0747.

    Phylogenomic databases

    HOGENOMi HOG000284153.
    KOi K14656.
    OMAi IVLGHDQ.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .
    BioCyci ABOO439481:GJNL-767-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_02115. FAD_synth_arch.
    InterProi IPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Electron microscopy encounters with unusual thermophiles helps direct genomic analysis of Aciduliprofundum boonei."
      Reysenbach A.L., Flores G.E.
      Geobiology 6:331-336(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19572 / T469.
    2. "Complete sequence of Aciduliprofundum boonei T469."
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Mikhailova N., Flores G., Reysenbach A.-L., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 19572 / T469.

    Entry informationi

    Entry nameiRIBL_ACIB4
    AccessioniPrimary (citable) accession number: B5I9H4
    Secondary accession number(s): B5IC32
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3