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Protein
Submitted name:

Cephalosporin hydroxylase CmcI

Gene

cmcI

Organism
Streptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi17Iron-sulfur (4Fe-4S-S-AdoMet); via carbonyl oxygenCombined sources1
Metal bindingi18Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi64Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi65Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi87Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi89Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi90Iron-sulfur (4Fe-4S-S-AdoMet); via carbonyl oxygenCombined sources1
Metal bindingi91Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi95Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Binding sitei95S-adenosyl-L-homocysteineCombined sources1
Metal bindingi116Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi117Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi121Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Binding sitei121S-adenosyl-L-homocysteineCombined sources1
Metal bindingi138Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi139Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi160Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Metal bindingi161Iron-sulfur (4Fe-4S-S-AdoMet)Combined sources1
Binding sitei161S-adenosyl-L-homocysteineCombined sources1
Binding sitei187S-adenosyl-L-homocysteineCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand4Fe-4SCombined sources, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cephalosporin hydroxylase CmcIImported
Gene namesi
Name:cmcIImported
ORF Names:SCLAV_4208Imported, SSCG_00137Imported
OrganismiStreptomyces clavuligerus (strain ATCC 27064 / DSM 738 / JCM 4710 / NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602)Imported
Taxonomic identifieri443255 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000002357 Componenti: Chromosome
  • UP000006569 Componenti: Unassembled WGS sequence

Interactioni

Protein-protein interaction databases

STRINGi443255.SclaA2_010100020188.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BM8X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L1-236[»]
2BM9X-ray2.94A/B/C/D/E/F1-236[»]
2BR3X-ray2.79A/B/C/D/E/F1-236[»]
2BR4X-ray2.59A/B/C/D/E/F1-236[»]
2BR5X-ray2.83A/B/C/D/E/F1-236[»]
SMRiB5GLB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 65S-adenosyl-L-homocysteine bindingCombined sources2
Regioni87 – 91S-adenosyl-L-homocysteine bindingCombined sources5
Regioni116 – 117S-adenosyl-L-homocysteine bindingCombined sources2
Regioni138 – 139S-adenosyl-L-homocysteine bindingCombined sources2

Phylogenomic databases

eggNOGiENOG4105ZK3. Bacteria.
COG3510. LUCA.
OrthoDBiPOG091H0L8T.

Family and domain databases

InterProiView protein in InterPro
IPR007072. Rhamnosyl_O-MeTrfase_CmcI.
IPR029063. SAM-dependent_MTases.
PfamiView protein in Pfam
PF04989. CmcI. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

B5GLB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDYSRQNFL DLNLFRGLGE DPAYHPPVLT DRPRDWPLDR WAEAPRDLGY
60 70 80 90 100
SDFSPYQWRG LRMLKDPDTQ AVYHDMLWEL RPRTIVELGV YNGGSLAWFR
110 120 130 140 150
DLTKIMGIDC QVIGIDRDLS RCQIPASDME NITLHQGDCS DLTTFEHLRE
160 170 180 190 200
MAHPLIFIDD AHANTFNIMK WAVDHLLEEG DYFIIEDMIP YWYRYAPQLL
210 220 230
SEYLGAFRDV LSMDMLYANA SSQLDRGVLR RVAAKQ
Length:236
Mass (Da):27,584
Last modified:October 14, 2008 - v1
Checksum:iFD1EF1B650AF8070
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH006362 Genomic DNA. Translation: AAC32491.1.
DS570624 Genomic DNA. Translation: EDY47109.1.
CM000913 Genomic DNA. Translation: EFG09283.1.
RefSeqiWP_003952496.1. NZ_DS570624.1.

Genome annotation databases

EnsemblBacteriaiEDY47109; EDY47109; SSCG_00137.
EFG09283; EFG09283; SCLAV_4208.

Similar proteinsi

Entry informationi

Entry nameiB5GLB3_STRC2
AccessioniPrimary (citable) accession number: B5GLB3
Secondary accession number(s): O85726
Entry historyiIntegrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: August 30, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported