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Protein

Molybdopterin synthase catalytic subunit

Gene

MOCS2

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.UniRule annotation

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].UniRule annotation

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei125 – 1251SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Enzyme and pathway databases

ReactomeiR-TGU-947581. Molybdenum cofactor biosynthesis.
UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunitUniRule annotation (EC:2.8.1.12UniRule annotation)
Alternative name(s):
Molybdenum cofactor synthesis protein 2 large subunitUniRule annotation
Molybdenum cofactor synthesis protein 2BUniRule annotation
Short name:
MOCS2BUniRule annotation
Gene namesi
Name:MOCS2UniRule annotation
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Chromosome Z

Subcellular locationi

  • Cytoplasmcytosol UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 155155Molybdopterin synthase catalytic subunitPRO_0000369328Add
BLAST

Interactioni

Subunit structurei

Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.UniRule annotation

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000002489.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni109 – 1102Substrate bindingUniRule annotation
Regioni132 – 1343Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the MoaE family. MOCS2B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3307. Eukaryota.
COG0314. LUCA.
GeneTreeiENSGT00510000047669.
HOGENOMiHOG000280877.
InParanoidiB5FXU9.
KOiK03635.
OMAiMHAANVG.
OrthoDBiEOG091G0CV5.
TreeFamiTF314334.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
HAMAPiMF_03052. MOC2B. 1 hit.
InterProiIPR028888. MOCS2B_euk.
IPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PANTHERiPTHR23404:SF2. PTHR23404:SF2. 1 hit.
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FXU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEREDAPKD FIKLKSEKLS VGEVSELVVS PYCGAVSLFI GTTRNNFEGK
60 70 80 90 100
KVIHLEYEAY TSMAETEMKK ICRDVRQKWP SVKHIAVHHR LGVVPITEAS
110 120 130 140 150
VIIAVSSPHR AESLEAVMYC INTLKASVPI WKKEIYEDEY SWKENKECFW

ANSEK
Length:155
Mass (Da):17,795
Last modified:October 14, 2008 - v1
Checksum:iA1CBF243EA33895F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71A → V in ACH43861 (PubMed:17018643).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ213601 mRNA. Translation: ACH43860.1.
DQ213602 mRNA. Translation: ACH43861.1.
RefSeqiNP_001232386.1. NM_001245457.2.
UniGeneiTgu.11071.

Genome annotation databases

EnsembliENSTGUT00000002513; ENSTGUP00000002489; ENSTGUG00000002421.
GeneIDi100190070.
KEGGitgu:100190070.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ213601 mRNA. Translation: ACH43860.1.
DQ213602 mRNA. Translation: ACH43861.1.
RefSeqiNP_001232386.1. NM_001245457.2.
UniGeneiTgu.11071.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000002489.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSTGUT00000002513; ENSTGUP00000002489; ENSTGUG00000002421.
GeneIDi100190070.
KEGGitgu:100190070.

Organism-specific databases

CTDi4338.

Phylogenomic databases

eggNOGiKOG3307. Eukaryota.
COG0314. LUCA.
GeneTreeiENSGT00510000047669.
HOGENOMiHOG000280877.
InParanoidiB5FXU9.
KOiK03635.
OMAiMHAANVG.
OrthoDBiEOG091G0CV5.
TreeFamiTF314334.

Enzyme and pathway databases

UniPathwayiUPA00344.
ReactomeiR-TGU-947581. Molybdenum cofactor biosynthesis.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
HAMAPiMF_03052. MOC2B. 1 hit.
InterProiIPR028888. MOCS2B_euk.
IPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PANTHERiPTHR23404:SF2. PTHR23404:SF2. 1 hit.
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOC2B_TAEGU
AccessioniPrimary (citable) accession number: B5FXU9
Secondary accession number(s): B5FXV0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.