B5FXD0 (B5FXD0_TAEGU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: Proteasome subunit alpha type RuleBase RU000551 EC=3.4.25.1 RuleBase RU000551
Organism	Taeniopygia guttata (Zebra finch) (Poephila guttata) EMBL ACH43691.1
Taxonomic identifier	59729 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Passeriformes › Passeroidea › Estrildidae › Estrildinae › Taeniopygia

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551
Catalytic activity	Cleavage of peptide bonds with very broad specificity. RuleBase RU000551
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551
Subcellular location	Cytoplasm. Nucleus By similarity RuleBase RU000551.
Sequence similarities	Belongs to the peptidase T1A family. RuleBase RU000551

Ontologies

Keywords
Cellular component	Cytoplasm RuleBase RU000551 Nucleus SAAS SAAS000426 RuleBase RU000551 Proteasome RuleBase RU000551 EMBL ACH43691.1
Molecular function	Hydrolase Protease Threonine protease RuleBase RU000551
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B5FXD0 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 6671F2F8DC529880	FASTA	246	27,449
	10 20 30 40 50 60 MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDSAVI VTQKKVPDKL 70 80 90 100 110 120 LDSNTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYDIP VDMLCKRIAD 130 140 150 160 170 180 ISQVYTQNAE MRPLGCCMIL IGIDEEHGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE 190 200 210 220 230 240 KKVKKKFDWT YEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDVHLV ALAERD

References

[1]

"A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes." Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V., Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S., Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P., Hayashizaki Y., Carninci P., Jarvis E.D. Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006) [PubMed: 17018643] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Whole brain EMBL ACH43691.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ213268 mRNA. Translation: ACH43691.1.
RefSeq	NP_001232198.1. NM_001245269.1.
UniGene	Tgu.11200.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B5FXD0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSTGUT00000012478; ENSTGUP00000012341; ENSTGUG00000011976.
GeneID	100189999.
KEGG	tgu:100189999.
Phylogenomic databases
GeneTree	ENSGT00550000074807.
HOVERGEN	HBG107363.
OMA	GKDCAVV.
OrthoDB	EOG4BP1CH.
Family and domain databases
InterPro	IPR000426. Proteasome_asu_N. IPR023332. Proteasome_suA-type. IPR001353. Proteasome_sua/b. [Graphical view]
KO	K02730.
Pfam	PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. [Graphical view]
SMART	SM00948. Proteasome_A_N. 1 hit. [Graphical view]
PROSITE	PS00388. PROTEASOME_A_1. 1 hit. PS51475. PROTEASOME_A_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B5FXD0_TAEGU

Accession

Primary (citable) accession number: B5FXD0

Entry history

Integrated into UniProtKB/TrEMBL:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)