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B5FRD9

- UNG_SALDC

UniProt

B5FRD9 - UNG_SALDC

Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

    Catalytic activityi

    Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. uracil DNA N-glycosylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. base-excision repair Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA repair

    Enzyme and pathway databases

    BioCyciSENT439851:GH2Z-2945-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
    Short name:
    UDGUniRule annotation
    Gene namesi
    Name:ungUniRule annotation
    Ordered Locus Names:SeD_A2975
    OrganismiSalmonella dublin (strain CT_02021853)
    Taxonomic identifieri439851 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008322: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Uracil-DNA glycosylasePRO_1000096602Add
    BLAST

    Proteomic databases

    PRIDEiB5FRD9.

    Interactioni

    Protein-protein interaction databases

    STRINGi439851.SeD_A2975.

    Structurei

    3D structure databases

    ProteinModelPortaliB5FRD9.
    SMRiB5FRD9. Positions 1-229.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the uracil-DNA glycosylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0692.
    HOGENOMiHOG000229528.
    OMAiWARQGVM.
    OrthoDBiEOG6MSS63.

    Family and domain databases

    Gene3Di3.40.470.10. 1 hit.
    HAMAPiMF_00148. UDG.
    InterProiIPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view]
    PANTHERiPTHR11264. PTHR11264. 1 hit.
    PfamiPF03167. UDG. 1 hit.
    [Graphical view]
    SMARTiSM00986. UDG. 1 hit.
    [Graphical view]
    SUPFAMiSSF52141. SSF52141. 1 hit.
    TIGRFAMsiTIGR00628. ung. 1 hit.
    PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5FRD9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATELTWHDV LADEKQQPYF INTLHTVAGE RQSGITVYPP QKDVFNAFRF    50
    TELGDVKVVI LGQDPYHGPG QAHGLAFSVR PGIAPPPSLV NMYKELEASI 100
    PGFVRPAHGY LESWARQGVL LLNTVLTVRA GQAHSHASLG WETFTDKVIS 150
    LINQHREGVV FLLWGSHAQK KGAIIDPQRH HILKAPHPSP LSAHRGFFGC 200
    NHFALTNQWL EQHGEKTIDW TPVLPAESE 229
    Length:229
    Mass (Da):25,480
    Last modified:October 14, 2008 - v1
    Checksum:i3612099383E42FB0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74756.1.
    RefSeqiYP_002216662.1. NC_011205.1.

    Genome annotation databases

    EnsemblBacteriaiACH74756; ACH74756; SeD_A2975.
    PATRICi18494065. VBISalEnt111443_2960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74756.1 .
    RefSeqi YP_002216662.1. NC_011205.1.

    3D structure databases

    ProteinModelPortali B5FRD9.
    SMRi B5FRD9. Positions 1-229.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439851.SeD_A2975.

    Proteomic databases

    PRIDEi B5FRD9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH74756 ; ACH74756 ; SeD_A2975 .
    PATRICi 18494065. VBISalEnt111443_2960.

    Phylogenomic databases

    eggNOGi COG0692.
    HOGENOMi HOG000229528.
    OMAi WARQGVM.
    OrthoDBi EOG6MSS63.

    Enzyme and pathway databases

    BioCyci SENT439851:GH2Z-2945-MONOMER.

    Family and domain databases

    Gene3Di 3.40.470.10. 1 hit.
    HAMAPi MF_00148. UDG.
    InterProi IPR018085. Ura-DNA_Glyclase_AS.
    IPR002043. Ura_DNA_glycsylse.
    IPR005122. Uracil-DNA_glycosylase-like.
    [Graphical view ]
    PANTHERi PTHR11264. PTHR11264. 1 hit.
    Pfami PF03167. UDG. 1 hit.
    [Graphical view ]
    SMARTi SM00986. UDG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52141. SSF52141. 1 hit.
    TIGRFAMsi TIGR00628. ung. 1 hit.
    PROSITEi PS00130. U_DNA_GLYCOSYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT_02021853.

    Entry informationi

    Entry nameiUNG_SALDC
    AccessioniPrimary (citable) accession number: B5FRD9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3