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Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-4571-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:SeD_A4629
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Glycerol-3-phosphate acyltransferasePRO_1000123090Add
BLAST

Proteomic databases

PRIDEiB5FQQ9.

Structurei

3D structure databases

ProteinModelPortaliB5FQQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi305 – 3106HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FQQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGWPRIYYK LLNLPLSILV KSKSIPAEPA QELGLDTSRP IMYVLPYNSK
60 70 80 90 100
ADLLTLRAQC LAHDLPDPLE PLEIDGALLP RYVFIHGGPR VFTYYTPKEE
110 120 130 140 150
SVKLFHDYLD LHRSNPALDV QMVPVSVMFG RAPGREKGED NPPLRMLNGV
160 170 180 190 200
QKFFAISWLG RDSFVRFSPS VSLRRMADEH GTDKIIAQKL ARVARMHFAR
210 220 230 240 250
QRLAAVGPRL PARQDLFNKL LASKAIARAV EDEARSKKIS HEKAQQNAIA
260 270 280 290 300
LMEEIAANFS YEMIRLTDRI LGFTWNRLYQ GINVHNAERV RQLAHDGHEI
310 320 330 340 350
VYVPCHRSHM DYLLLSYVLY HQGLVPPHIA AGINLNFWPA GPIFRRLGAF
360 370 380 390 400
FIRRTFKGNK LYSTVFREYL GELFSRGYSV EYFVEGGRSR TGRLLDPKTG
410 420 430 440 450
TLSMTIQAML RGGTRPITLV PIYIGYEHVM EVGTYAKELR GATKEKESLP
460 470 480 490 500
QMLKGLSKLR NLGQGYVNFG EPMPLMTYLN QHVPEWRESI DPIEAIRPAW
510 520 530 540 550
LTPTVNSIAA DLMVRINNAG AANAMNLCCT ALLASRQRSL TREQLTEQLD
560 570 580 590 600
CYLDLMRNVP YSTDSTVPAA SAGELIAHAL QMNKFEVEKD TIGDIIILPR
610 620 630 640 650
EQAVLMTYYR NNIAHMLIMP SLMAAIITQH RRISRDALQQ HVEALYPMLK
660 670 680 690 700
AELFLRWERE ELASVIDALA SEMQRQGLIT LQDDELHINP THSRTLQLLA
710 720 730 740 750
AGARETLQRY AITFWLLSAN PSINRSTLEK ESRTVAQRLS VLHGINAPEF
760 770 780 790 800
FDKAVFSSLV LTLRDEGYIS DTGDAEPAET MKIYQMLADL ITSDVRLTIE

SATQGE
Length:806
Mass (Da):91,227
Last modified:October 14, 2008 - v1
Checksum:i9D6FE34757B8F9ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH77280.1.
RefSeqiWP_000017360.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH77280; ACH77280; SeD_A4629.
KEGGised:SeD_A4629.
PATRICi18497297. VBISalEnt111443_4522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH77280.1.
RefSeqiWP_000017360.1. NC_011205.1.

3D structure databases

ProteinModelPortaliB5FQQ9.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB5FQQ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH77280; ACH77280; SeD_A4629.
KEGGised:SeD_A4629.
PATRICi18497297. VBISalEnt111443_4522.

Phylogenomic databases

HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciSENT439851:GH2Z-4571-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_SALDC
AccessioniPrimary (citable) accession number: B5FQQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.