B5FQL1 (NUDC_SALDC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH pyrophosphatase
EC=3.6.1.22

Gene names

Name:	nudC
Ordered Locus Names:	SeD_A4573

Organism

Salmonella dublin (strain CT_02021853) [Complete proteome] [HAMAP]

Taxonomic identifier

439851 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella choleraesuis › Salmonella enterica I › Salmonella dublin

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	NAD+ + H2O = AMP + NMN. HAMAP-Rule MF_00297
Cofactor	Divalent metal cations. Magnesium or manganese By similarity. Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. NudC subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Ligand	Magnesium Manganese Metal-binding NAD Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	NAD+ diphosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	NADH pyrophosphatase HAMAP-Rule MF_00297		PRO_1000115247
Regions
	Domain	125 – 248	124	Nudix hydrolase
	Motif	159 – 180	22	Nudix box HAMAP-Rule MF_00297
Sites
	Metal binding	98	1	Zinc By similarity
	Metal binding	101	1	Zinc By similarity
	Metal binding	116	1	Zinc By similarity
	Metal binding	119	1	Zinc By similarity
	Metal binding	174	1	Divalent metal cation By similarity
	Metal binding	178	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	B5FQL1 [UniParc]. Last modified October 14, 2008. Version 1. Checksum: 19B99052BD428C78	FASTA	257	29,607
	10 20 30 40 50 60 MDRIIEKLES GWWIVSHEQK LWLPYGELPH GLAANFDLVG QRALRIGEWQ GEPVWLVLQH 70 80 90 100 110 120 RRHDMGSVRQ VIDQDAGLFQ LAGRGVQLAE FYRSHKFCGY CGHPMHPSKT EWAMLCSHCR 130 140 150 160 170 180 ERYYPQIAPC IIVAIRREDS ILLAQHVRHR NGVHTVLAGF VEVGETLEQA VAREVMEESG 190 200 210 220 230 240 IKVKNLRYVT SQPWPFPQSL MTAFMAEYDS GEIVIDPKEL LEANWYRYDD LPLLPPPGTV 250 ARRLIEDTVA MCRAEYD

References

[1]

"Complete genome of Salmonella dublin strain CT_02021853." Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CT_02021853.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001144 Genomic DNA. Translation: ACH74052.1.
RefSeq	YP_002218082.1. NC_011205.1.
3D structure databases
ProteinModelPortal	B5FQL1.
SMR	B5FQL1. Positions 1-257.
ModBase	Search...
Protein-protein interaction databases
STRING	439851.SeD_A4573.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACH74052; ACH74052; SeD_A4573.
GeneID	6874610.
KEGG	sed:SeD_A4573.
PATRIC	18497188. VBISalEnt111443_4472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2816.
HOGENOM	HOG000247937.
KO	K03426.
OMA	TELACLC.
ProtClustDB	PRK00241.
Enzyme and pathway databases
BioCyc	SENT439851:GH2Z-493-MONOMER.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
HAMAP	MF_00297. Nudix_NudC.
InterPro	IPR022925. NADH_pyroPase_NudC. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR015376. Znr_NADH_PPase. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. PF09297. zf-NADH-PPase. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 2 hits.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUDC_SALDC

Accession

Primary (citable) accession number: B5FQL1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	October 14, 2008
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program