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B5FQL1

- NUDC_SALDC

UniProt

B5FQL1 - NUDC_SALDC

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Protein
NADH pyrophosphatase
Gene
nudC, SeD_A4573
Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

NAD+ + H2O = AMP + NMN.UniRule annotation

Cofactori

Divalent metal cations. Magnesium or manganese By similarity.
Binds 1 zinc ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Zinc By similarity
Metal bindingi101 – 1011Zinc By similarity
Metal bindingi116 – 1161Zinc By similarity
Metal bindingi119 – 1191Zinc By similarity
Metal bindingi174 – 1741Divalent metal cation By similarity
Metal bindingi178 – 1781Divalent metal cation By similarity

GO - Molecular functioni

  1. NAD+ diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciSENT439851:GH2Z-4516-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH pyrophosphatase (EC:3.6.1.22)
    Gene namesi
    Name:nudC
    Ordered Locus Names:SeD_A4573
    OrganismiSalmonella dublin (strain CT_02021853)
    Taxonomic identifieri439851 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008322: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 257257NADH pyrophosphataseUniRule annotation
    PRO_1000115247Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi439851.SeD_A4573.

    Structurei

    3D structure databases

    ProteinModelPortaliB5FQL1.
    SMRiB5FQL1. Positions 1-257.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini125 – 248124Nudix hydrolase
    Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi159 – 18022Nudix boxUniRule annotation
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2816.
    HOGENOMiHOG000247937.
    OMAiACLCHHC.
    OrthoDBiEOG6S26JD.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    HAMAPiMF_00297. Nudix_NudC.
    InterProiIPR022925. NADH_pyroPase_NudC.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR015376. Znr_NADH_PPase.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    PF09297. zf-NADH-PPase. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 2 hits.
    PROSITEiPS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5FQL1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRIIEKLES GWWIVSHEQK LWLPYGELPH GLAANFDLVG QRALRIGEWQ    50
    GEPVWLVLQH RRHDMGSVRQ VIDQDAGLFQ LAGRGVQLAE FYRSHKFCGY 100
    CGHPMHPSKT EWAMLCSHCR ERYYPQIAPC IIVAIRREDS ILLAQHVRHR 150
    NGVHTVLAGF VEVGETLEQA VAREVMEESG IKVKNLRYVT SQPWPFPQSL 200
    MTAFMAEYDS GEIVIDPKEL LEANWYRYDD LPLLPPPGTV ARRLIEDTVA 250
    MCRAEYD 257
    Length:257
    Mass (Da):29,607
    Last modified:October 14, 2008 - v1
    Checksum:i19B99052BD428C78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74052.1.
    RefSeqiYP_002218082.1. NC_011205.1.

    Genome annotation databases

    EnsemblBacteriaiACH74052; ACH74052; SeD_A4573.
    PATRICi18497188. VBISalEnt111443_4472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74052.1 .
    RefSeqi YP_002218082.1. NC_011205.1.

    3D structure databases

    ProteinModelPortali B5FQL1.
    SMRi B5FQL1. Positions 1-257.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 439851.SeD_A4573.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH74052 ; ACH74052 ; SeD_A4573 .
    PATRICi 18497188. VBISalEnt111443_4472.

    Phylogenomic databases

    eggNOGi COG2816.
    HOGENOMi HOG000247937.
    OMAi ACLCHHC.
    OrthoDBi EOG6S26JD.

    Enzyme and pathway databases

    BioCyci SENT439851:GH2Z-4516-MONOMER.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    HAMAPi MF_00297. Nudix_NudC.
    InterProi IPR022925. NADH_pyroPase_NudC.
    IPR020084. NUDIX_hydrolase_CS.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    IPR015376. Znr_NADH_PPase.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    PF09297. zf-NADH-PPase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 2 hits.
    PROSITEi PS51462. NUDIX. 1 hit.
    PS00893. NUDIX_BOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT_02021853.

    Entry informationi

    Entry nameiNUDC_SALDC
    AccessioniPrimary (citable) accession number: B5FQL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 14, 2008
    Last modified: July 9, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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