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Protein

NADH pyrophosphatase

Gene

nudC

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(H) + H2O = AMP + NMN(H).UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Divalent metal cations. Mg2+ or Mn2+.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98ZincUniRule annotation1
Metal bindingi101ZincUniRule annotation1
Metal bindingi116ZincUniRule annotation1
Metal bindingi119ZincUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi178Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Manganese, Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NADH pyrophosphataseUniRule annotation (EC:3.6.1.22UniRule annotation)
Gene namesi
Name:nudCUniRule annotation
Ordered Locus Names:SeD_A4573
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001152471 – 257NADH pyrophosphataseAdd BLAST257

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB5FQL1
SMRiB5FQL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 248Nudix hydrolaseUniRule annotationAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi159 – 180Nudix boxAdd BLAST22

Sequence similaritiesi

Belongs to the Nudix hydrolase family. NudC subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000247937
KOiK03426
OMAiFHAEYAG

Family and domain databases

HAMAPiMF_00297 Nudix_NudC, 1 hit
InterProiView protein in InterPro
IPR022925 NADH_pyroPase_NudC
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR020084 NUDIX_hydrolase_CS
IPR000086 NUDIX_hydrolase_dom
IPR015376 Znr_NADH_PPase
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PF09297 zf-NADH-PPase, 1 hit
SUPFAMiSSF55811 SSF55811, 2 hits
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit
PS00893 NUDIX_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

B5FQL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRIIEKLES GWWIVSHEQK LWLPYGELPH GLAANFDLVG QRALRIGEWQ
60 70 80 90 100
GEPVWLVLQH RRHDMGSVRQ VIDQDAGLFQ LAGRGVQLAE FYRSHKFCGY
110 120 130 140 150
CGHPMHPSKT EWAMLCSHCR ERYYPQIAPC IIVAIRREDS ILLAQHVRHR
160 170 180 190 200
NGVHTVLAGF VEVGETLEQA VAREVMEESG IKVKNLRYVT SQPWPFPQSL
210 220 230 240 250
MTAFMAEYDS GEIVIDPKEL LEANWYRYDD LPLLPPPGTV ARRLIEDTVA

MCRAEYD
Length:257
Mass (Da):29,607
Last modified:October 14, 2008 - v1
Checksum:i19B99052BD428C78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA Translation: ACH74052.1
RefSeqiWP_000373958.1, NC_011205.1

Genome annotation databases

EnsemblBacteriaiACH74052; ACH74052; SeD_A4573
KEGGised:SeD_A4573

Similar proteinsi

Entry informationi

Entry nameiNUDC_SALDC
AccessioniPrimary (citable) accession number: B5FQL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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