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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2626-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Protein family/group databases

MEROPSiS33.996.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:SeD_A2652
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_1000187115Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi439851.SeD_A2652.

Structurei

3D structure databases

ProteinModelPortaliB5FPE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
OMAiAGHNAHQ.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FPE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLHAQHMPG QPGTSSLVFL HGFSGDCREW QPVGEQFHGC SRLYIDLPGH
60 70 80 90 100
GGSAAIPVGG FADVIRLLRA TLISYNILKF WLVGYSLGGR VAMMAACQGI
110 120 130 140 150
PGLCGLVVEG GHPGLQNEQA RAERRLSDGR WAERFRHEPL TEVFHDWYQQ
160 170 180 190 200
PVFASLTAQQ RQALTALRSQ NNGETLAAML EATSLAVQPD LREALNALAF
210 220 230 240 250
PFYYLCGERD SKFRALAQEV AATCHVIRNA GHNAHRENPA GVVDSLAQIL

RL
Length:252
Mass (Da):27,643
Last modified:October 14, 2008 - v1
Checksum:iAB9E09740EBE2A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1.
RefSeqiYP_002216376.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH75058; ACH75058; SeD_A2652.
PATRICi18493435. VBISalEnt111443_2652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1.
RefSeqiYP_002216376.1. NC_011205.1.

3D structure databases

ProteinModelPortaliB5FPE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi439851.SeD_A2652.

Protein family/group databases

MEROPSiS33.996.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACH75058; ACH75058; SeD_A2652.
PATRICi18493435. VBISalEnt111443_2652.

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
OMAiAGHNAHQ.
OrthoDBiEOG689HPM.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00900.
BioCyciSENT439851:GH2Z-2626-MONOMER.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
TIGRFAMsiTIGR03695. menH_SHCHC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiMENH_SALDC
AccessioniPrimary (citable) accession number: B5FPE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: April 29, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.