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B5FPE7 (MENH_SALDC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Short name=SHCHC synthase
EC=4.2.99.20
Gene names
Name:menH
Ordered Locus Names:SeD_A2652
OrganismSalmonella dublin (strain CT_02021853) [Complete proteome] [HAMAP]
Taxonomic identifier439851 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro By similarity. HAMAP-Rule MF_01660

Catalytic activity

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate. HAMAP-Rule MF_01660

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 3/8. HAMAP-Rule MF_01660

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01660

Sequence similarities

Belongs to the AB hydrolase superfamily. MenH family.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase HAMAP-Rule MF_01660
PRO_1000187115

Sequences

Sequence LengthMass (Da)Tools
B5FPE7 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: AB9E09740EBE2A24

FASTA25227,643
        10         20         30         40         50         60 
MMLHAQHMPG QPGTSSLVFL HGFSGDCREW QPVGEQFHGC SRLYIDLPGH GGSAAIPVGG 

        70         80         90        100        110        120 
FADVIRLLRA TLISYNILKF WLVGYSLGGR VAMMAACQGI PGLCGLVVEG GHPGLQNEQA 

       130        140        150        160        170        180 
RAERRLSDGR WAERFRHEPL TEVFHDWYQQ PVFASLTAQQ RQALTALRSQ NNGETLAAML 

       190        200        210        220        230        240 
EATSLAVQPD LREALNALAF PFYYLCGERD SKFRALAQEV AATCHVIRNA GHNAHRENPA 

       250 
GVVDSLAQIL RL 

« Hide

References

[1]"Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT_02021853.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001144 Genomic DNA. Translation: ACH75058.1.
RefSeqYP_002216376.1. NC_011205.1.

3D structure databases

ProteinModelPortalB5FPE7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439851.SeD_A2652.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH75058; ACH75058; SeD_A2652.
PATRIC18493435. VBISalEnt111443_2652.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0596.
HOGENOMHOG000028072.
OMALGGRIAM.
OrthoDBEOG689HPM.

Enzyme and pathway databases

BioCycSENT439851:GH2Z-2626-MONOMER.
UniPathwayUPA00079; UER00900.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
HAMAPMF_01660. MenH.
InterProIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
TIGRFAMsTIGR03695. menH_SHCHC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMENH_SALDC
AccessionPrimary (citable) accession number: B5FPE7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways