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B5FPE7

- MENH_SALDC

UniProt

B5FPE7 - MENH_SALDC

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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2626-MONOMER.
UniPathwayiUPA00079.
UPA01057; UER00900.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:SeD_A2652
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthasePRO_1000187115Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi439851.SeD_A2652.

Structurei

3D structure databases

ProteinModelPortaliB5FPE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
OMAiLGGRIAM.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FPE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLHAQHMPG QPGTSSLVFL HGFSGDCREW QPVGEQFHGC SRLYIDLPGH
60 70 80 90 100
GGSAAIPVGG FADVIRLLRA TLISYNILKF WLVGYSLGGR VAMMAACQGI
110 120 130 140 150
PGLCGLVVEG GHPGLQNEQA RAERRLSDGR WAERFRHEPL TEVFHDWYQQ
160 170 180 190 200
PVFASLTAQQ RQALTALRSQ NNGETLAAML EATSLAVQPD LREALNALAF
210 220 230 240 250
PFYYLCGERD SKFRALAQEV AATCHVIRNA GHNAHRENPA GVVDSLAQIL

RL
Length:252
Mass (Da):27,643
Last modified:October 14, 2008 - v1
Checksum:iAB9E09740EBE2A24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1.
RefSeqiYP_002216376.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH75058; ACH75058; SeD_A2652.
PATRICi18493435. VBISalEnt111443_2652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1 .
RefSeqi YP_002216376.1. NC_011205.1.

3D structure databases

ProteinModelPortali B5FPE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439851.SeD_A2652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH75058 ; ACH75058 ; SeD_A2652 .
PATRICi 18493435. VBISalEnt111443_2652.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028072.
OMAi LGGRIAM.
OrthoDBi EOG689HPM.

Enzyme and pathway databases

UniPathwayi UPA00079 .
UPA01057 ; UER00900 .
BioCyci SENT439851:GH2Z-2626-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01660. MenH.
InterProi IPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiMENH_SALDC
AccessioniPrimary (citable) accession number: B5FPE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3