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B5FPE7

- MENH_SALDC

UniProt

B5FPE7 - MENH_SALDC

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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene
menH, SeD_A2652
Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro By similarity.UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. menaquinone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Menaquinone biosynthesis

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2626-MONOMER.
UniPathwayiUPA00079; UER00900.

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (EC:4.2.99.20)
Short name:
SHCHC synthase
Gene namesi
Name:menH
Ordered Locus Names:SeD_A2652
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2522522-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotationPRO_1000187115Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi439851.SeD_A2652.

Structurei

3D structure databases

ProteinModelPortaliB5FPE7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0596.
HOGENOMiHOG000028072.
OMAiLGGRIAM.
OrthoDBiEOG689HPM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01660. MenH.
InterProiIPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FPE7-1 [UniParc]FASTAAdd to Basket

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MMLHAQHMPG QPGTSSLVFL HGFSGDCREW QPVGEQFHGC SRLYIDLPGH    50
GGSAAIPVGG FADVIRLLRA TLISYNILKF WLVGYSLGGR VAMMAACQGI 100
PGLCGLVVEG GHPGLQNEQA RAERRLSDGR WAERFRHEPL TEVFHDWYQQ 150
PVFASLTAQQ RQALTALRSQ NNGETLAAML EATSLAVQPD LREALNALAF 200
PFYYLCGERD SKFRALAQEV AATCHVIRNA GHNAHRENPA GVVDSLAQIL 250
RL 252
Length:252
Mass (Da):27,643
Last modified:October 14, 2008 - v1
Checksum:iAB9E09740EBE2A24
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1.
RefSeqiYP_002216376.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH75058; ACH75058; SeD_A2652.
PATRICi18493435. VBISalEnt111443_2652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH75058.1 .
RefSeqi YP_002216376.1. NC_011205.1.

3D structure databases

ProteinModelPortali B5FPE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439851.SeD_A2652.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH75058 ; ACH75058 ; SeD_A2652 .
PATRICi 18493435. VBISalEnt111443_2652.

Phylogenomic databases

eggNOGi COG0596.
HOGENOMi HOG000028072.
OMAi LGGRIAM.
OrthoDBi EOG689HPM.

Enzyme and pathway databases

UniPathwayi UPA00079 ; UER00900 .
BioCyci SENT439851:GH2Z-2626-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01660. MenH.
InterProi IPR029058. AB_hydrolase.
IPR022485. SHCHC_synthase_MenH.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiMENH_SALDC
AccessioniPrimary (citable) accession number: B5FPE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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