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B5FMW2

- THIM_SALDC

UniProt

B5FMW2 - THIM_SALDC

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, SeD_A2491
Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Substrate; via amide nitrogen By similarity
Binding sitei125 – 1251ATP By similarity
Binding sitei171 – 1711ATP By similarity
Binding sitei198 – 1981Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2469-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:SeD_A2491
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Hydroxyethylthiazole kinaseUniRule annotationPRO_1000100419Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439851.SeD_A2491.

Structurei

3D structure databases

ProteinModelPortaliB5FMW2.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FMW2-1 [UniParc]FASTAAdd to Basket

« Hide

MQPDLHCRTL AAHTLKHFRA LSPLTHCMTN DVVQTFTANT LLALGASPAM    50
VIDPVEARPF AAIANALLIN VGTLTASRAD AMRAAVESAY DAKTPWTLDP 100
VAVGALEFRR RFCLDLLSLR PAAIRGNASE ILALSGMALG GRGVDTTEAA 150
LAALPAAQAL ARQIDCIVVV TGEIDYVTNG QRTLSIPGGD PLMTRIVGTG 200
CALSAVVAAS CALPGAALDN VASACCWMKL AGQAAAERSE GPGSFIPAFL 250
DALYHLDVEA ANATN 265
Length:265
Mass (Da):27,422
Last modified:October 14, 2008 - v1
Checksum:iE8B6A99B12275677
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH75157.1.
RefSeqiYP_002216230.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH75157; ACH75157; SeD_A2491.
PATRICi18493110. VBISalEnt111443_2491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH75157.1 .
RefSeqi YP_002216230.1. NC_011205.1.

3D structure databases

ProteinModelPortali B5FMW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439851.SeD_A2491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH75157 ; ACH75157 ; SeD_A2491 .
PATRICi 18493110. VBISalEnt111443_2491.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SENT439851:GH2Z-2469-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiTHIM_SALDC
AccessioniPrimary (citable) accession number: B5FMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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