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B5FKB4 (B5FKB4_SALDC) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:SeD_A2176
OrganismSalmonella dublin (strain CT_02021853) [Complete proteome] [HAMAP] EMBL ACH74743.1
Taxonomic identifier439851 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella › Salmonella dublin

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region245 – 2495ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2441 By similarity HAMAP MF_01815
Active site2741 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B5FKB4 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 53EE64342C4EDAEF

FASTA31733,524
        10         20         30         40         50         60 
MYTKIIGTGS YLPEQVRTNA DLEKMVETSD EWIVTRTGIR ERHIAAPNET VATMGFTAAN 

        70         80         90        100        110        120 
RAIEMAGIDK DQIGLIVVAT TSATHAFPSA ACQIQSMLGI KGCPAFDVAA ACAGFTYALS 

       130        140        150        160        170        180 
IADQYVKSGA VKHALVVGSD VLARTCDPGD RGTIIIFGDG AGAAVLSASE EPGIISTHLH 

       190        200        210        220        230        240 
ADGRYGELLT LPNADRVNPD NPIYLTMAGN EVFKVAVTEL AHIVDETLAA NNLDRSELDW 

       250        260        270        280        290        300 
LVPHQANLRI ISATAKKLGM SMDNVVVTLD RHGNTSAASV PCALDEAVRD GRIKAGQLVL 

       310 
LEAFGGGFTW GSALIRF

« Hide

References

[1]"Complete genome of Salmonella dublin strain CT_02021853."
Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001144 Genomic DNA. Translation: ACH74743.1.
RefSeqYP_002215945.1. NC_011205.1.

3D structure databases

ProteinModelPortalB5FKB4.
SMRB5FKB4. Positions 1-317.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5FKB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6875289.
GenomeReviewsGene locus SeD_A2176 in contig CP001144_GR.
KEGGsed:SeD_A2176.
PATRIC18492502. VBISalEnt111443_2193.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMARILNFLA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5FKB4_SALDC
AccessionPrimary (citable) accession number: B5FKB4
Entry history
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info