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B5FJD4

- ASTE_SALDC

UniProt

B5FJD4 - ASTE_SALDC

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Protein
Succinylglutamate desuccinylase
Gene
astE, SeD_A2039
Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate By similarity.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Zinc By similarity
Metal bindingi56 – 561Zinc By similarity
Metal bindingi147 – 1471Zinc By similarity
Active sitei210 – 2101 Reviewed prediction

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2022-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylase (EC:3.5.1.96)
Gene namesi
Name:astE
Ordered Locus Names:SeD_A2039
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Succinylglutamate desuccinylaseUniRule annotation
PRO_1000133639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439851.SeD_A2039.

Structurei

3D structure databases

ProteinModelPortaliB5FJD4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
OMAiTAPIEIC.
OrthoDBiEOG613070.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FJD4-1 [UniParc]FASTAAdd to Basket

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MDNFLALTLS GTTPRVTQGK SAGFRWRWLG HGLLELTPDA PVDRALILSA    50
GIHGNETAPV EMLDKLLSAL FSGSLTLTWR VLVVLGNPQA LAAGIRYCHS 100
DMNRMFGGRW QSFAESDETR RARELELSLE TFFSSGHARV RWHLDLHTAI 150
RGSHHLRFGV LPQRDRPWET DFLAWLGAAG LEALVFHQAP GGTFTHFSSE 200
HFGALSCALE LGKALPFRQN DLTQFNVTSQ ALSALLSGVE TSTSFSPPLR 250
YRVVSQITRH SDKFALYMDA QTLNFTAFAK GTLLAEEGDK RVTVTHDVEY 300
VLFPNPSVAC GLRAGLMLER LP 322
Length:322
Mass (Da):35,634
Last modified:October 14, 2008 - v1
Checksum:iE2884FC6C1C232C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH74276.1.
RefSeqiYP_002215819.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH74276; ACH74276; SeD_A2039.
PATRICi18492240. VBISalEnt111443_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001144 Genomic DNA. Translation: ACH74276.1 .
RefSeqi YP_002215819.1. NC_011205.1.

3D structure databases

ProteinModelPortali B5FJD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439851.SeD_A2039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH74276 ; ACH74276 ; SeD_A2039 .
PATRICi 18492240. VBISalEnt111443_2064.

Phylogenomic databases

eggNOGi COG2988.
HOGENOMi HOG000280300.
OMAi TAPIEIC.
OrthoDBi EOG613070.

Enzyme and pathway databases

UniPathwayi UPA00185 ; UER00283 .
BioCyci SENT439851:GH2Z-2022-MONOMER.

Family and domain databases

HAMAPi MF_00767. Arg_catab_AstE.
InterProi IPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view ]
Pfami PF04952. AstE_AspA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiASTE_SALDC
AccessioniPrimary (citable) accession number: B5FJD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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