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B5FJD4

- ASTE_SALDC

UniProt

B5FJD4 - ASTE_SALDC

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Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

Catalytic activityi

N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531ZincUniRule annotation
Metal bindingi56 – 561ZincUniRule annotation
Metal bindingi147 – 1471ZincUniRule annotation
Active sitei210 – 2101UniRule annotation

GO - Molecular functioni

  1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
  2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
  2. arginine catabolic process to succinate Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSENT439851:GH2Z-2022-MONOMER.
UniPathwayiUPA00185; UER00283.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
Gene namesi
Name:astEUniRule annotation
Ordered Locus Names:SeD_A2039
OrganismiSalmonella dublin (strain CT_02021853)
Taxonomic identifieri439851 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
ProteomesiUP000008322: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Succinylglutamate desuccinylasePRO_1000133639Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi439851.SeD_A2039.

Structurei

3D structure databases

ProteinModelPortaliB5FJD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2988.
HOGENOMiHOG000280300.
OMAiTAPIEIC.
OrthoDBiEOG613070.

Family and domain databases

HAMAPiMF_00767. Arg_catab_AstE.
InterProiIPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view]
PfamiPF04952. AstE_AspA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

Sequencei

Sequence statusi: Complete.

B5FJD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNFLALTLS GTTPRVTQGK SAGFRWRWLG HGLLELTPDA PVDRALILSA
60 70 80 90 100
GIHGNETAPV EMLDKLLSAL FSGSLTLTWR VLVVLGNPQA LAAGIRYCHS
110 120 130 140 150
DMNRMFGGRW QSFAESDETR RARELELSLE TFFSSGHARV RWHLDLHTAI
160 170 180 190 200
RGSHHLRFGV LPQRDRPWET DFLAWLGAAG LEALVFHQAP GGTFTHFSSE
210 220 230 240 250
HFGALSCALE LGKALPFRQN DLTQFNVTSQ ALSALLSGVE TSTSFSPPLR
260 270 280 290 300
YRVVSQITRH SDKFALYMDA QTLNFTAFAK GTLLAEEGDK RVTVTHDVEY
310 320
VLFPNPSVAC GLRAGLMLER LP
Length:322
Mass (Da):35,634
Last modified:October 14, 2008 - v1
Checksum:iE2884FC6C1C232C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH74276.1.
RefSeqiYP_002215819.1. NC_011205.1.

Genome annotation databases

EnsemblBacteriaiACH74276; ACH74276; SeD_A2039.
PATRICi18492240. VBISalEnt111443_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001144 Genomic DNA. Translation: ACH74276.1 .
RefSeqi YP_002215819.1. NC_011205.1.

3D structure databases

ProteinModelPortali B5FJD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 439851.SeD_A2039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACH74276 ; ACH74276 ; SeD_A2039 .
PATRICi 18492240. VBISalEnt111443_2064.

Phylogenomic databases

eggNOGi COG2988.
HOGENOMi HOG000280300.
OMAi TAPIEIC.
OrthoDBi EOG613070.

Enzyme and pathway databases

UniPathwayi UPA00185 ; UER00283 .
BioCyci SENT439851:GH2Z-2022-MONOMER.

Family and domain databases

HAMAPi MF_00767. Arg_catab_AstE.
InterProi IPR007036. Aste_AspA.
IPR016681. SuccinylGlu_desuccinylase.
[Graphical view ]
Pfami PF04952. AstE_AspA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
    Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
    J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CT_02021853.

Entry informationi

Entry nameiASTE_SALDC
AccessioniPrimary (citable) accession number: B5FJD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 14, 2008
Last modified: November 26, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3