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B5FJD4

- ASTE_SALDC

UniProt

B5FJD4 - ASTE_SALDC

Protein

Succinylglutamate desuccinylase

Gene

astE

Organism
Salmonella dublin (strain CT_02021853)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Transforms N(2)-succinylglutamate into succinate and glutamate.UniRule annotation

    Catalytic activityi

    N-succinyl-L-glutamate + H2O = succinate + L-glutamate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531ZincUniRule annotation
    Metal bindingi56 – 561ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Active sitei210 – 2101UniRule annotation

    GO - Molecular functioni

    1. hydrolase activity, acting on ester bonds Source: UniProtKB-HAMAP
    2. succinylglutamate desuccinylase activity Source: UniProtKB-EC
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process to glutamate Source: UniProtKB-HAMAP
    2. arginine catabolic process to succinate Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSENT439851:GH2Z-2022-MONOMER.
    UniPathwayiUPA00185; UER00283.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinylglutamate desuccinylaseUniRule annotation (EC:3.5.1.96UniRule annotation)
    Gene namesi
    Name:astEUniRule annotation
    Ordered Locus Names:SeD_A2039
    OrganismiSalmonella dublin (strain CT_02021853)
    Taxonomic identifieri439851 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
    ProteomesiUP000008322: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322Succinylglutamate desuccinylasePRO_1000133639Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi439851.SeD_A2039.

    Structurei

    3D structure databases

    ProteinModelPortaliB5FJD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2988.
    HOGENOMiHOG000280300.
    OMAiTAPIEIC.
    OrthoDBiEOG613070.

    Family and domain databases

    HAMAPiMF_00767. Arg_catab_AstE.
    InterProiIPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view]
    PfamiPF04952. AstE_AspA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03242. arg_catab_astE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B5FJD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNFLALTLS GTTPRVTQGK SAGFRWRWLG HGLLELTPDA PVDRALILSA    50
    GIHGNETAPV EMLDKLLSAL FSGSLTLTWR VLVVLGNPQA LAAGIRYCHS 100
    DMNRMFGGRW QSFAESDETR RARELELSLE TFFSSGHARV RWHLDLHTAI 150
    RGSHHLRFGV LPQRDRPWET DFLAWLGAAG LEALVFHQAP GGTFTHFSSE 200
    HFGALSCALE LGKALPFRQN DLTQFNVTSQ ALSALLSGVE TSTSFSPPLR 250
    YRVVSQITRH SDKFALYMDA QTLNFTAFAK GTLLAEEGDK RVTVTHDVEY 300
    VLFPNPSVAC GLRAGLMLER LP 322
    Length:322
    Mass (Da):35,634
    Last modified:October 14, 2008 - v1
    Checksum:iE2884FC6C1C232C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74276.1.
    RefSeqiYP_002215819.1. NC_011205.1.

    Genome annotation databases

    EnsemblBacteriaiACH74276; ACH74276; SeD_A2039.
    PATRICi18492240. VBISalEnt111443_2064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001144 Genomic DNA. Translation: ACH74276.1 .
    RefSeqi YP_002215819.1. NC_011205.1.

    3D structure databases

    ProteinModelPortali B5FJD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 439851.SeD_A2039.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH74276 ; ACH74276 ; SeD_A2039 .
    PATRICi 18492240. VBISalEnt111443_2064.

    Phylogenomic databases

    eggNOGi COG2988.
    HOGENOMi HOG000280300.
    OMAi TAPIEIC.
    OrthoDBi EOG613070.

    Enzyme and pathway databases

    UniPathwayi UPA00185 ; UER00283 .
    BioCyci SENT439851:GH2Z-2022-MONOMER.

    Family and domain databases

    HAMAPi MF_00767. Arg_catab_AstE.
    InterProi IPR007036. Aste_AspA.
    IPR016681. SuccinylGlu_desuccinylase.
    [Graphical view ]
    Pfami PF04952. AstE_AspA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03242. arg_catab_astE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
      Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
      J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CT_02021853.

    Entry informationi

    Entry nameiASTE_SALDC
    AccessioniPrimary (citable) accession number: B5FJD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3