Skip Header

Contribute Send feedback
Read comments (?) or add your own

B5FIB4 (SPEE_SALDC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Spermidine synthase
EC=2.5.1.16
Alternative name(s):
Putrescine aminopropyltransferase
Short name=PAPT
SPDSY
Gene names
Name:speE
Ordered Locus Names:SeD_A0181
OrganismSalmonella dublin (strain CT_02021853) [Complete proteome] [HAMAP]
Taxonomic identifier439851 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Salmonella ›

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor By similarity. HAMAP-Rule MF_00198

Catalytic activity

S-adenosylmethioninamine + putrescine = S-methyl-5'-thioadenosine + spermidine. HAMAP-Rule MF_00198

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. HAMAP-Rule MF_00198

Subunit structure

Homodimer and homotetramer By similarity. HAMAP-Rule MF_00198

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Ontologies

Keywords
   Biological processPolyamine biosynthesis
Spermidine biosynthesis
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processspermidine biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionspermidine synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Spermidine synthase HAMAP-Rule MF_00198
PRO_1000099294

Regions

Region140 – 1412S-adenosylmethioninamine binding By similarity

Sites

Active site1581Proton acceptor By similarity
Binding site331S-adenosylmethioninamine By similarity
Binding site631Putrescine By similarity
Binding site881S-adenosylmethioninamine By similarity
Binding site1081S-adenosylmethioninamine By similarity
Binding site1611Putrescine By similarity
Binding site2261Putrescine By similarity

Sequences

Sequence LengthMass (Da)Tools
B5FIB4 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 9D7B2E2A045C8287

FASTA28632,095
        10         20         30         40         50         60 
MAENTMWHET LHDQFGQYFA VDNVLYHEKT DHQDLIIFEN AAFGRVMALD GVVQTTERDE 

        70         80         90        100        110        120 
FIYHEMMTHV PLLAHGHAKH VLIIGGGDGA MLREVTRHKN VETITMVEID AGVVSFCRQY 

       130        140        150        160        170        180 
LPNHNAGSYD DPRFTLVIDD GVNFVNQTHQ TFDVIISDCT DPIGPGESLF TSAFYEGCKR 

       190        200        210        220        230        240 
CLNPGGIFVA QNGVCFLQQD EALDSHRKLS HYFSDVGFYQ AAIPTYYGGI MTFAWATDND 

       250        260        270        280 
ALRHLSSEII QARFHAAGLK CRYYNPAIHA AAFALPQYLH DALSAQ

« Hide

References

[1]"Complete genome of Salmonella dublin strain CT_02021853."
Ravel J., Fricke W.F., White D., McDermott P., Mammel M., Rosovitz M., Leclerc J., Cebula T., Sebastian Y.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT_02021853.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001144 Genomic DNA. Translation: ACH74476.1.
RefSeqYP_002214122.1. NC_011205.1.

3D structure databases

ProteinModelPortalB5FIB4.
ModBaseSearch...

Protein-protein interaction databases

STRING439851.SeD_A0181.

Proteomic databases

PRIDEB5FIB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH74476; ACH74476; SeD_A0181.
GeneID6875497.
KEGGsed:SeD_A0181.
PATRIC18488583. VBISalEnt111443_0268.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0421.
HOGENOMHOG000256146.
KOK00797.
OMAELWYTEK.
ProtClustDBPRK00811.

Enzyme and pathway databases

BioCycSENT439851:GH2Z-176-MONOMER.
UniPathwayUPA00248; UER00314.

Family and domain databases

HAMAPMF_00198. Spermidine_synth.
InterProIPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERPTHR11558. PTHR11558. 1 hit.
PfamPF01564. Spermine_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00417. speE. 1 hit.
PROSITEPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEE_SALDC
AccessionPrimary (citable) accession number: B5FIB4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 14, 2008
Last modified: May 29, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents