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B5FI74 (B5FI74_SALDC) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:SeD_A0139 EMBL ACH74377.1
OrganismSalmonella dublin (strain CT_02021853) [Complete proteome] [HAMAP] EMBL ACH74377.1
Taxonomic identifier439851 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain80 – 282203ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding113 – 16856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2361Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2491Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2491Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2511Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
B5FI74 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: EB7C85F83C2831C3

FASTA28530,546
        10         20         30         40         50         60 
MADKIAVLLG GTSAERDVSL NSGAAVLAGL REGGIDAHPV DPQEVDVAQL KAMGFQKVFI 

        70         80         90        100        110        120 
ALHGRGVMAS ALSMDKLRSK LLWQGAGLPV APWVALTRAE FEKGLSEEQK ARISALGLPL 

       130        140        150        160        170        180 
IVKPSREGSS VGMTKVVEEN ALQGALSLAF QHDDEILIEK WLCGPEFTVA IVGEEILPSI 

       190        200        210        220        230        240 
RIQPAGTFYD YEAKYLSDET QYFCPAGLDA SQEAALQSLV LQAWKALGCT GWGRIDVMLD 

       250        260        270        280 
SDGQFYLLEA NTSPGMTSHS LVPMAARQAG MSFSQLVVRI LELAD 

« Hide

References

[1]"Comparative genomics of 28 Salmonella enterica isolates: evidence for CRISPR-mediated adaptive sublineage evolution."
Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G., Leclerc J.E., Ravel J., Cebula T.A.
J. Bacteriol. 193:3556-3568(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CT_02021853 EMBL ACH74377.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001144 Genomic DNA. Translation: ACH74377.1.
RefSeqYP_002214082.1. NC_011205.1.

3D structure databases

ProteinModelPortalB5FI74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING439851.SeD_A0139.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACH74377; ACH74377; SeD_A0139.
PATRIC18488501. VBISalEnt111443_0227.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
OMACLLEANT.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycSENT439851:GH2Z-135-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB5FI74_SALDC
AccessionPrimary (citable) accession number: B5FI74
Entry history
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)