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B5FG41 (B5FG41_VIBFM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III HAMAP MF_01815
Beta-ketoacyl-ACP synthase III HAMAP MF_01815
Gene names
Name:fabH HAMAP MF_01815
Ordered Locus Names:VFMJ11_1869
OrganismVibrio fischeri (strain MJ11) [Complete proteome] [HAMAP] EMBL ACH65539.1
Taxonomic identifier388396 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region245 – 2495ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2441 By similarity HAMAP MF_01815
Active site2741 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B5FG41 [UniParc].

Last modified October 14, 2008. Version 1.
Checksum: 27BE9AC523588F88

FASTA31733,968
        10         20         30         40         50         60 
MYSKILGTGS YLPAQIRSNA DLEKMVDTSD EWILARTGIS ERRIAGEDES VATMAHLASV 

        70         80         90        100        110        120 
NAIEMAGIDK NDIDLIILAT STPTYSFPSA ACEVQGLLGI QGCPAFDLSA ACSGFVYALS 

       130        140        150        160        170        180 
VADQHIKTGM AKNVLVIGSD AVSHTCDPED RSTIILFGDG AGAVVLGQSE EPGIISTHLH 

       190        200        210        220        230        240 
ADGKFGELLS LPVPSRKNEE ADKWLYMAGN EVFKVAVTQL SNLVKETLQE NQMDKSELDW 

       250        260        270        280        290        300 
LVPHQANLRI IKATAKKLSM SMDQVVVTLD RHGNTSAATV PTALDEAVRD GRIQRGQTLL 

       310 
LEAFGGGFTW GSALVKF

« Hide

References

[1]"Complete sequence of Vibrio fischeri strain MJ11."
Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001139 Genomic DNA. Translation: ACH65539.1.
RefSeqYP_002156564.1. NC_011184.1.

3D structure databases

ProteinModelPortalB5FG41.
SMRB5FG41. Positions 1-317.
ModBaseSearch...

Protein-protein interaction databases

STRINGB5FG41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6807180.
GenomeReviewsGene locus VFMJ11_1869 in contig CP001139_GR.
KEGGvfm:VFMJ11_1869.
PATRIC20122202. VBIVibFis37164_1792.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMARILNFLA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB5FG41_VIBFM
AccessionPrimary (citable) accession number: B5FG41
Entry history
Integrated into UniProtKB/TrEMBL: October 14, 2008
Last sequence update: October 14, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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