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B5FF86

- GPPA_VIBFM

UniProt

B5FF86 - GPPA_VIBFM

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Vibrio fischeri (strain MJ11)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:VFMJ11_0053
    OrganismiVibrio fischeri (strain MJ11)
    Taxonomic identifieri388396 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio
    ProteomesiUP000001857: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000192541Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi388396.VFMJ11_0053.

    Structurei

    3D structure databases

    ProteinModelPortaliB5FF86.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B5FF86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSSTIPPMY AAIDLGSNSF HMLVVRHING SVQTMAKIKR KVRLAAGLNE    50
    NNTLSHEAMQ RGWDCLSLFA ERLQDIPVEN IRIVGTATLR VASNVDIFLE 100
    KANQILGHNI NVIEGEEEAR MIYQGVAHTS GGNGRRLVVD IGGASTELII 150
    GEGFEAQALT SLKMGCVTWL EGYFKDRALT QKNFDSAIAG AKETLAPILQ 200
    QYTDLGWQTC VGASGTVQAL QEIMLAQGMD EVITLAKLKR LQKQAMQYEH 250
    LEELDIDGLT LERALVFPSG LSILIAIFEL LNIDSMTLAG GALREGLCYG 300
    MIDELQHDEV CQRTIKSTQQ RYQLDVEYAQ QVTDLSIQLV QQCGNDWLTE 350
    PQALPLLTAA TQLHEIGMCI DYKKGGEHSA YLINALDLPG FTRAQKHLLG 400
    ELLRRYREYF SAMPTQHAVS DISAQRMLRI LRLAIILTHR RDVNLAPAVT 450
    LSEKNDVLSL SIDGTWLAAN PLTRSELEIE ADKQTNIGWD LVIDARD 497
    Length:497
    Mass (Da):55,112
    Last modified:October 14, 2008 - v1
    Checksum:i022C81EDB74A0475
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001139 Genomic DNA. Translation: ACH65095.1.
    RefSeqiYP_002154824.1. NC_011184.1.

    Genome annotation databases

    EnsemblBacteriaiACH65095; ACH65095; VFMJ11_0053.
    GeneIDi6806879.
    KEGGivfm:VFMJ11_0053.
    PATRICi20118559. VBIVibFis37164_0053.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001139 Genomic DNA. Translation: ACH65095.1 .
    RefSeqi YP_002154824.1. NC_011184.1.

    3D structure databases

    ProteinModelPortali B5FF86.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 388396.VFMJ11_0053.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACH65095 ; ACH65095 ; VFMJ11_0053 .
    GeneIDi 6806879.
    KEGGi vfm:VFMJ11_0053.
    PATRICi 20118559. VBIVibFis37164_0053.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Vibrio fischeri strain MJ11."
      Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
      Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MJ11.

    Entry informationi

    Entry nameiGPPA_VIBFM
    AccessioniPrimary (citable) accession number: B5FF86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3