Reviewed,
UniProtKB/Swiss-Prot B5FEQ9 (TPMT_VIBFM)
Last modified
January 19, 2010.
Version 11.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Thiopurine S-methyltransferase EC=2.1.1.67 Alternative name(s): Thiopurine methyltransferase | ||||
| Gene names |
| ||||
| Organism | Vibrio fischeri (strain MJ11) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 388396 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio |
Protein attributes
| Sequence length | 213 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00812. |
| Sequence similarities | Belongs to the methyltransferase superfamily. TPMT family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | S-adenosyl-L-methionine |
| Molecular function | Methyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | thiopurine S-methyltransferase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 213 | 213 | Thiopurine S-methyltransferase HAMAP MF_00812 | PRO_1000134082 | |||||
Sites | |||||||||
| Binding site | 10 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 45 | 1 | S-adenosyl-L-methionine; via carbonyl oxygen By similarity | ||||||
| Binding site | 66 | 1 | S-adenosyl-L-methionine By similarity | ||||||
| Binding site | 121 | 1 | S-adenosyl-L-methionine By similarity | ||||||
Sequences
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References
| [1] | "Complete sequence of Vibrio fischeri strain MJ11." Mandel M.J., Stabb E.V., Ruby E.G., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C. Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP001139 Genomic DNA. Translation: ACH65974.1. |
| RefSeq | YP_002156324.1. |
3D structure databases | |
| SMR | B5FEQ9. Positions 1-212. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 6805927. |
| GenomeReviews | Gene locus VFMJ11_1605 in contig CP001139_GR. |
| KEGG | vfm:VFMJ11_1605. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG444929. |
| OMA | GKSLDMC. |
Family and domain databases | |
| HAMAP | MF_00812. Thiopur_methtran. [Tree] |
| InterPro | IPR008854. Thiopurine_S-MeTrfase. IPR016822. Thiopurine_S-MeTrfase_sub. [Graphical view] |
| Pfam | PF05724. TPMT. 1 hit. [Graphical view] |
| PIRSF | PIRSF023956. Thiopurine_S-methyltransferase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | TPMT_VIBFM | ||||||||
| Accession | Primary (citable) accession number: B5FEQ9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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